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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제5호
- 발행연도
- 2017.1
- 수록면
- 1,032 - 1,037 (6page)
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초록· 키워드
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The poly-γ-D-glutamic acid (PGA) capsule, a major virulence factor of Bacillus anthracis, provides protection of the bacterium from phagocytosis and allows its unimpeded growth in the host. We investigated crosstalk between murine natural killer (NK) cells and macrophages stimulated with the PGA capsule of Bacillus licheniformis, a surrogate of the B. anthracis capsule. PGA induced interferon-gamma production from NK cells cultured with macrophages. This effect was dependent on macrophage-derived IL-12 and cell-cell contact interaction with macrophages through NK cell receptor NKG2D and its ligand RAE-1. The results showed that PGA could enhance NK cell activation by inducing IL-12 production in macrophages and a contact-dependent crosstalk with macrophages.
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참고문헌 (23)
참고문헌 신청
Birrer GA / 1994 / Gammapoly(glutamic acid) formation by Bacillus licheniformis 9945a:physiological and biological studies / Int. J. Biol. Macromol 16 : 265 ~ 275
Bozzano F / 2011 / Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined tr
Gates-Hollingsworth MA / 2015 / Immunoassay for capsular antigen of Bacillus anthracis enables rapid diagnosis in a rabbit model of inhalational anthrax / PLoS One 10 : e012
Gold JA / 2004 / Exogenous gamma and alpha/beta interferon rescues human macrophages from cell death induced by Bacillusanthracis / Infect. Immun 72 : 1291 ~ 1297
Gonzales CM / 2012 / Antibacterial role for natural killer cells in host defense to Bacillus anthracis / Infect. Immun 80 : 234 ~ 242
Bozzano F / 2011 / Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined tr
Gates-Hollingsworth MA / 2015 / Immunoassay for capsular antigen of Bacillus anthracis enables rapid diagnosis in a rabbit model of inhalational anthrax / PLoS One 10 : e012
Gold JA / 2004 / Exogenous gamma and alpha/beta interferon rescues human macrophages from cell death induced by Bacillusanthracis / Infect. Immun 72 : 1291 ~ 1297
Gonzales CM / 2012 / Antibacterial role for natural killer cells in host defense to Bacillus anthracis / Infect. Immun 80 : 234 ~ 242
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