지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 8 - 151 (144page)
이용수
초록· 키워드
오류제보하기
The mechanism of inhibitory action of bisphospho-nates on bone resorption is not fully elucidated.Osteoclast formation and activity are regulated byosteoblast-derived factors such as the osteoclast dif-ferentiating factor, receptor activator of NF-kappaBligand (RANKL) and the inhibitor, osteoprotegerin(OPG). To investigate in vitro effects of bisphospho-nates on mouse osteoblastic cells, we examined theexpression levels of RANKL and OPG in the cellstreated with alendronate or pamidronate (10-8~10-5 M)alone, or combined with 10 nM of 1,25-(OH) 2VitD3 for24 or 48 h. Various concentrations of alendronateand pamidronate did not change the mRNA expres-sion of RANKL and OPG consistently irrespectiveof 1,25-(OH)2VitD3 presence. When aded into coc-ultures of mouse osteoblastic cells and bone mar-row cells, both alendronate and pamidronateinhibited osteoclast formation and bone resorptionbut failed to alter the RANKL and OPG mRNAexpression. These results indicate that the inhibi-tion of bone resorption by bisphosphonates is notmediated by the regulation of RANKL and OPGexpression.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Receptor activator of NF-κB ligand enhances the activity of macrophages as antigen presenting cells
Experimental and Molecular Medicine
2005 .01
-
Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis
Experimental and Molecular Medicine
2019 .01
-
대사증후군 남성에서의 혈중 Osteoprotegerin의 아디포넥틴과의 상관성과 비만도에 따른 차이
대한지역사회영양학회지
2011 .12
-
The Effects of Rosiglitazone on Osteoblastic Differentiation, Osteoclast Formation and Bone Resorption
Molecules and Cells
2012 .01
-
운동 형태가 흰쥐의 뼈형성에 미치는 영향
한국영양학회지
2001 .07
-
Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1
Molecules and Cells
2019 .01
-
RANKL 유도된 파골세포 분화에 대한 풀무치 에탄올 추출물의 분화 억제 효과
생명과학회지
2019 .10
-
Spi-C positively regulates RANKL-mediated osteoclast differentiation and function
Experimental and Molecular Medicine
2020 .01
-
The Role of Receptor Activator of NF-кB Ligand in Smooth Muscle Cell Proliferation
생명과학회지
2006 .10
-
Antimicrobial agents, outer membrane assembly machine, lipoprotein, lipopolysaccharide, outer membrane β-barrel protein, phospholipid
Journal of Microbiology and Biotechnology
2019 .01
-
High extracellular Ca2+ alone stimulates osteoclast formation but inhibits in the presence of other osteoclastogenic factors
Experimental and Molecular Medicine
2003 .01
-
ST5 Positively Regulates Osteoclastogenesis via Src/Syk/calcium Signaling Pathways
Molecules and Cells
2019 .01
-
Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species
Experimental and Molecular Medicine
2011 .01
-
Rutin inhibits osteoclast formation by decreasing reactiveoxygen species and TNF-α by inhibiting activation of NF-κ BAccepted 28 November 2007a glycoside of flavonol,
Experimental and Molecular Medicine
2008 .01
-
Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
Experimental and Molecular Medicine
2015 .01
-
RANKL stimulates proliferation, adhesion and IL-7 expression of thymic epithelial cells
Experimental and Molecular Medicine
2008 .01
-
Inhibitory effect of Ssanghwa-tang on bone loss in ovariectomized rats
Animal cells and systems
2010 .01
-
A FKBP5 mutation is associated with Paget’s disease of bone and enhances osteoclastogenesis
Experimental and Molecular Medicine
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0