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Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-γ
Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-γ
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한생화학·분자생물학회 Experimental and Molecular Medicine Experimental and Molecular Medicine 제36권 제6호 KCI Accredited Journals SCI
- 발행연도
- 2004.1
- 수록면
- 534 - 544 (11page)
이용수
Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-γ
초록· 키워드
오류제보하기
During chronic inflamatory response, mono- cytes/macrophages produce 92-kDa matrix meta-loproteinase-9 (MP-9), which may contribute to their extravasation, migration and tissue re-modeling. Activation of peroxisome proliferator- activated factor receptor-γ (PPAR-γ) has been shown to inhibit MMP-9 activity. To evaluate whether ox-LDL, a PAR-γ activator, inhibits PMA-induced MP-9 expresion and activity, and if so, whether CD36 and PPAR-γ are in-fect of ox-LDL on MMP-9 expresion and activity in PMA-activated human monocytic cell line U937. PMA-induced MMP-9 expresion and ac-tivity were supressed by the treatment with ox-LDL (50 g/ml) or PPAR-γ activators such as troglitazone (5 M), ciglitazone (5 M), and 15d- PGJ2 (1 M) for 24 h. This ox-LDL or PPAR-γ activator-mediated inhibition of MP-9 activity was diminished by the pre-treatment of cels with a blocking antibody to CD36, or PGF2α (0.3 M), which is a PPAR-γ inhibitor, as wel as overexpresion of a dominant-negative form of CD36. Taken together, these results sugest that ox-LDL suppresses PMA-induced MMP-9 ex-presion and activity through CD36-mediated activation of PAR-γ.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
/ 1855-8 / Prostaglandinspromote and block adipogenesis through opposingeffects on peroxisome proliferator-activated receptorgamma
/ 1992 / Nomaneclature andglossary of the matrix metalloproteinase : 421 ~ 24
/ 1996 / Synergistictranscriptional activation of the tissue inhibitor ofmetalloproteinases-1 promoter via functional interaction ofAP-1 and its transcription factors : 7774
/ 1997 / Native andmodified low density lipoproteins increase the functionalexpression of the macrophage class B scavenger receptor : 21654 ~ 9
/ 1998 / Oxidized LDL regulates macrophage gene expressionthrough ligand activation of PPAR-γ tonto (z p) : 229 ~ 40
/ 1992 / Nomaneclature andglossary of the matrix metalloproteinase : 421 ~ 24
/ 1996 / Synergistictranscriptional activation of the tissue inhibitor ofmetalloproteinases-1 promoter via functional interaction ofAP-1 and its transcription factors : 7774
/ 1997 / Native andmodified low density lipoproteins increase the functionalexpression of the macrophage class B scavenger receptor : 21654 ~ 9
/ 1998 / Oxidized LDL regulates macrophage gene expressionthrough ligand activation of PPAR-γ tonto (z p) : 229 ~ 40
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