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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 715 - 721 (7page)
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초록· 키워드
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Excessive production of nitric oxide (NO) and proin-flammatory cytokines from activated microglia play an Here, we investigated whether celastrol, which has been used as a potent anti-inflammatory and anti-oxi-dative agent in Chinese medicine, attenuates ex-cessive production of NO and proinflammatory cyto-kines such as TNF-α and IL-1β in LPS-stimulated BV-2 cells, a mouse microglial cell line. We report here that the LPS-elicited excessive production of NO, TNF-α, and IL-1βence of celastrol, and the attenuation of inducible iNOS and these cytokines resulted from the reduced ex-pression of mRNAs of iNOS and these cytokines, respectively. The molecular mechanisms that underlie celastrol-mediated atenuation were the inhibition of LPS-induced phosphorylation of MAPK/ERK1/2 and the DNA binding activity of NF-κB in BV-2 cells. The results indicate that celastrol effectively attenuated inhibition of ERK1/2 phosphorylation and NF-κB ac-tivation in LPS-activated microglia. Thus, celastrol may be an effective therapeutic candidate for use in the treatment of neurodegenerative human brain disorders.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Allison AC / 2001 / Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease 25 : 1341 ~ 1357
Barron KD / 1995 / The microglial cell. A historical review 134 : 57 ~ 68
Bhat NR / 1998 / Extracellular signal- regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis fac
Chap CC / 1995 / Interleukin-1 and tumor necrosis factor-α synergistically mediate neuro-toxicity: involvement of nitric oxide and of N-methyl-D- aspartate receptors 9 : 355
Chen CJ / 2004 / Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/ cytokine-stimulated microglia 67 : 957 ~ 965
Barron KD / 1995 / The microglial cell. A historical review 134 : 57 ~ 68
Bhat NR / 1998 / Extracellular signal- regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis fac
Chap CC / 1995 / Interleukin-1 and tumor necrosis factor-α synergistically mediate neuro-toxicity: involvement of nitric oxide and of N-methyl-D- aspartate receptors 9 : 355
Chen CJ / 2004 / Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/ cytokine-stimulated microglia 67 : 957 ~ 965
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