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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제4호
- 발행연도
- 2008.1
- 수록면
- 686 - 694 (9page)
이용수
초록· 키워드
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The inhibitory effects of 5,6,3',5'-tetramethoxy 7,4'-
hydroxyflavone (labeled as p7F) were elucidated on
the productions of proinflammatory cytokines as well as
inflammatory mediators in human synovial fibroblasts
and macrophage cells. p7F inhibited IL-1β or TNF-α
induced expressions of inflammatory mediators (ICAM-1,
COX-2, and iNOS). p7F also inhibited LPS-induced
productions of nitric oxide and prostaglandin E2 in RAW
264.7 cells. In order to investigate whether p7F would
inhibit IL-1 signaling, p7F was added to the D10S Th2 cell
line (which is responsive to only IL-1β and thus proliferates),
revealing that p7F inhibited IL-1β-induced proliferation
of D10S Th2 cells in a dose-response manner. A flow
cytometric analysis revealed that p7F reduced the intracellular
level of free radical oxygen species in RAW 264.7 cells
treated with hydrogen peroxide. p7F inhibited IκB
degradation and NF-κB activation in macrophage cells
treated with LPS, supporting that p7F could inhibit
signaling mediated via toll-like receptor. Taken together,
p7F has inhibitory effects on LPS-induced productions of
inflammatory mediators on human synovial fibroblasts
and macrophage cells and thus has the potential to be an
anti-inflammatory agent for inhibiting inflammatory
responses.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
[학
Alcaraz, M. J. / 1985 / Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside,on prostaglandin biosynthesis and inactivation. Biochem / Pharma
Alzoreky, N. S. / 2003 / Antibacterial activity of extracts from some edible plants commonly consumed in Asia. Int. J. Food / Microbiol 15 : 223 ~ 230
Arend, W. P. / 2001 / Cytokine imbalance in the pathogenesis of rheumatoid arthritis: The role of interleukin-1 receptor antagonist. Semin. Arthritis / Rheum 30 : 1 ~ 6
Baeuerle, P. A. / 1994 / Function and activation of NF-κB in the immune system. Annu. Rev / Immunol 12 : 141 ~ 179
Alcaraz, M. J. / 1985 / Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside,on prostaglandin biosynthesis and inactivation. Biochem / Pharma
Alzoreky, N. S. / 2003 / Antibacterial activity of extracts from some edible plants commonly consumed in Asia. Int. J. Food / Microbiol 15 : 223 ~ 230
Arend, W. P. / 2001 / Cytokine imbalance in the pathogenesis of rheumatoid arthritis: The role of interleukin-1 receptor antagonist. Semin. Arthritis / Rheum 30 : 1 ~ 6
Baeuerle, P. A. / 1994 / Function and activation of NF-κB in the immune system. Annu. Rev / Immunol 12 : 141 ~ 179
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