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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 27 - 35 (9page)
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초록· 키워드
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Pulmonary hypertension (PH) is characterized by structural and functional changes in the lung including proliferation of vascular sm ooth m uscle cells (VSMCs) and excessive collagen synthesis. Although connective tissue growth factor (CTGF) is known to promote cell proliferation, migration, adhesion, and extracellular matrix production in various tissues, studies on the role of CTGF in pulmonary hypertension have been limited. Here, we examined CTGF expression in the lung tissues of male Sprague Dawley rats treated with monocrotaline (MCT, 60 µg/kg), a pneumotoxic agent known to induce PH in animals. Establishment of PH was verified by the significantly increased right ventricular systolic pressure and right ventricle/left ventricle weight ratio in the MCT-treated rats. Histological examination examination of the lung revealed profound muscular hypertrophy in the media of pulmonary artery and arterioles in MCT-treated group. Lung parenchyma, vein, and bronchiole did not appear to be affected. RT-PCR analysis of the lung tissue at 5 weeks indicated significantly increased expression of CTGF in the MCT-treated group. In situ hybridization studies also confirmed abundant CTGF mRNA expression in VSMCs of the arteries and arterioles, clustered pneumocytes, and infiltrated macrophages. Interestingly, CTGF mRNA was not detected in VSMCs of vein or bronchiole. In saline-injected control, basal expression of CTGF was seen in bronchial epithelial cells, alveolar lining cells, and endothelial cells. Taken together, our results suggest that CTGF upregulation in arterial VSMC of the lung might be important in the pathogenesis of pulmonary hypertension. Antagonizing the role of CTGF could thus be one of the potential approaches for the treatment of PH.
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참고문헌 (28)
참고문헌 신청
/ / Transforming growth factorbeta(1)induces apoptosis via connective tissue growthfactor in human aortic smooth muscle cells 385 : 287 ~ 90
/ 1967 / Cor pulmonale in rats 16 : 875 ~ 81
/ 1969 / Transforming growth factor beta induces anchorageindependentgrowth of NRK fibroblasts via a connectivetissue growth factor-dependent signaling pathway : 61 ~ 8
/ 1991 / Connective tissue growth factor:A cysteine-rich mitogensecreted by human vascular endothelial cells is related tothe SRC-induced immediate early gene product CEF-10
/ 1991 / Survival in patients with primary pulmonaryhypertension.Results from a national prospective registry 115 : 343 ~ 9
/ 1967 / Cor pulmonale in rats 16 : 875 ~ 81
/ 1969 / Transforming growth factor beta induces anchorageindependentgrowth of NRK fibroblasts via a connectivetissue growth factor-dependent signaling pathway : 61 ~ 8
/ 1991 / Connective tissue growth factor:A cysteine-rich mitogensecreted by human vascular endothelial cells is related tothe SRC-induced immediate early gene product CEF-10
/ 1991 / Survival in patients with primary pulmonaryhypertension.Results from a national prospective registry 115 : 343 ~ 9
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