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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 538 - 547 (10page)
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초록· 키워드
오류제보하기
Total aralosides of Aralia elata (Miq) Seem (TASAES)
from Chinese traditional herb Longya Aralia chinensis
L was found to improve cardiac function. The present
study was to determine the protective effects of
TASAES on diabetic cardiomyopathy, and the possible
mechanisms. Therefore, a single dose of streptozotocin
was used to induce diabetes in Wister rats.
Diabetic rats were immediately treated with low, medium
and high doses of TASAES at 4.9, 9.8 mg/kg and
19.6 mg/kg body weight by gavage, respectively, for
eight weeks. Cardiac function was evaluated by in situ
hemodynamic measurements, and patch clamp for the
L-type Ca2+ channel current (ICa2+-L) and transient outward
K+ channel current (Ito). Histopathological changes
were observed under light and electron microscope.
The expression of pro-fibrotic factor, connective tissue
growth factor (CTGF) was monitored using immunohistochemistry
staining. Compared with diabetic
group, medium and high doses, but not low dose,
of TASAES showed a significant protection against
diabetes-induced cardiac dysfunction, shown by increased
absolute value of left ventricular systolic pressure
(LVSP) and maximum rates of pressure development
(±dp/dtmax), and enhanced amplitude of ICa2+-L
(P ＜ 0.05). Histological staining indicated a significant
inhibition of diabetes-caused pathological
changes and up-regulation of CTGF expression (P ＜
0.05). The results suggest that TASAES prevents diabetes-
induced cardiac dysfunction and pathological
damage through up-regulating ICa2+-L in cardiac cells
and decreasing CTGF expression.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Cai L / 2002 / Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway / Diabetes 51 : 1938 ~ 1948
Cai L / 2005 / Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy / Diabetes 54 : 1829
Candio R / 2003 / A breaker of advance glycation end products at attenuates diabetes-induced myocardial structural changes / Circ Res 92 : 785 ~ 792
Chattou S / 1999 / Decrease in Sodiumcalcium exchange and calcium currents in diabetic rat ventricular myocytes / Acta Physiol Scand 166 : 137 ~ 144
Chujo S / 2005 / Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model
Cai L / 2005 / Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy / Diabetes 54 : 1829
Candio R / 2003 / A breaker of advance glycation end products at attenuates diabetes-induced myocardial structural changes / Circ Res 92 : 785 ~ 792
Chattou S / 1999 / Decrease in Sodiumcalcium exchange and calcium currents in diabetic rat ventricular myocytes / Acta Physiol Scand 166 : 137 ~ 144
Chujo S / 2005 / Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model
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