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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 229 - 236 (8page)
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Molecular mechanism of lung carcinogenesis and its aggressive nature is still largely elusive. To uncover the biomarkers related with tumorigenesis and behavior of lung cancer, we screened novel differentially expressed genes (DEG) in A549 lung cancer cell line by comparison with CCD-25Lu, normal pulmonary epithelial cell line, using annealing control primer(ACP)- based GeneFishing system. Of the DEGs, over-expression of leucyl-tRNA synthetase 1 (LARS1) was prominent and this up-regulation was confirmed by immunoblotting and real-time quantitative RT-PCR analysis. In addition to A549 cell line, primary lung cancer tissues also expressed higher level of LARS1 mRNA than their normal counter tissues. To explore the oncogenic potential of LARS1 over-expression in lung cancer, we knocked-down LARS1 by treating siRNA and observed the tumor behavior. LARS1 knock-down cells showed reduced ability to migrate through transwell membrane and to form colonies in both soft agar and culture plate. Taken together, these findings suggest that LARS1 may play roles in migration and growth of lung cancer cells, which suggest its potential implication in lung tumorigenesis.
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참고문헌 (26)
참고문헌 신청
Balsara BR / 2002 / Chromosomal imbalances in human lung cancer / Oncogene 21 : 6877 ~ 83
Boyle P / 2005 / Cancer incidence and mortality in Europe / Ann Oncol 16 : 481 ~ 8
Crnkovi?-Mertens I / 2006 / The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells / Lung Cancer 54 : 135
Eun Jeong Lee / 2007 / Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells / Experimental and Molecular Medicine 39 (4) : 4
Ferrigino D / 2003 / Neuron-specific enolase is an effective tumor marker in nonsmall cell lung cancer (NSCLC) / Lung Cancer 41 : 311 ~ 20
Boyle P / 2005 / Cancer incidence and mortality in Europe / Ann Oncol 16 : 481 ~ 8
Crnkovi?-Mertens I / 2006 / The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells / Lung Cancer 54 : 135
Eun Jeong Lee / 2007 / Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells / Experimental and Molecular Medicine 39 (4) : 4
Ferrigino D / 2003 / Neuron-specific enolase is an effective tumor marker in nonsmall cell lung cancer (NSCLC) / Lung Cancer 41 : 311 ~ 20
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