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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 116 - 125 (10page)
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Bone morphogenic protein 4 (BMP4), a member of the TGF-β superfamily, induced neural differentiation of neural stem cells (NSCs) grown in a medium containing basic fibroblast growth factor (bFGF). The Ras protein level and the activities of the downstream ERKs were increased by transfection of BMP4 or treatment with recombinant BMP4. The effects of BMP4, including activation of the Ras-ERK pathway and induction of the neuron marker β-tubulin type III (Tuj1), were blocked by co-treatment of the BMP4 antagonist, noggin. The roles of the Ras-ERK pathway in neuronal differentiation by BMP4 were revealed by measuring the effect of the ERK pathway inhibition by dominant negative Ras or PD98059, the MEK specific inhibitor. BMP4 is a transcriptional target of Wnt/β-catenin signaling, and both the mRNA and protein levels of BMP4 were increased by treatment of valproic acid (VPA), a chemical inhibitor of glycogen synthase kinase 3β (GSK3β) activating the Wnt/β-catenin pathway. The BMP4- mimicking effects of VPA, activation of the Ras-ERK pathway and induction of Tuj1, also were blocked by noggin. These results indicate the potential therapeutic usage of VPA as a replacement for BMP4.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Baker JC / 1999 / Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development / Genes Dev 13 : 3149 ~ 3159
Chen G / 1999 / The moodstabilizing agent valproate inhibits the activity of glycogen synthase kinase-3 / J Neurochem 72 : 1327 ~ 1330
Cobb MH / 1999 / MAP kinase pathways / Prog Biophys Mol Biol 71 : 479 ~ 500
Cui SS / 2003 / Valproic acid enhances axonal regeneration and recovery of motor function after sciatic nerve axotomy in adult rats / Brain Res 975 : 229 ~ 236
Dae-Soo Jung / 2007 / Effects of retinoic acid on ischemic brain injury-inducedneurogenesis / Experimental and Molecular Medicine 39 (3) : 304 ~ 315
Chen G / 1999 / The moodstabilizing agent valproate inhibits the activity of glycogen synthase kinase-3 / J Neurochem 72 : 1327 ~ 1330
Cobb MH / 1999 / MAP kinase pathways / Prog Biophys Mol Biol 71 : 479 ~ 500
Cui SS / 2003 / Valproic acid enhances axonal regeneration and recovery of motor function after sciatic nerve axotomy in adult rats / Brain Res 975 : 229 ~ 236
Dae-Soo Jung / 2007 / Effects of retinoic acid on ischemic brain injury-inducedneurogenesis / Experimental and Molecular Medicine 39 (3) : 304 ~ 315
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