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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제11호
- 발행연도
- 2009.1
- 수록면
- 1,355 - 1,363 (9page)
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초록· 키워드
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In the present study, the neuroprotective effects of astaxanthin
on H2O2-mediated apoptotic cell death, using cultured
mouse neural progenitor cells (mNPCs), were investigated.
To cause apoptotic cell death, mNPCs were pretreated
with astaxanthin for 8 h and followed by treatment of
0.3 mM H2O2. Pretreatment of mNPCs with astaxanthin
significantly inhibited H2O2-mediated apoptosis and induced
cell growth in a dose-dependent manner. In Western blot
analysis, astaxanthin-pretreated cells showed the activation
of p-Akt, p-MEK, p-ERK, and Bcl-2, and the reduction of
p-P38, p-SAPK/JNK, Bax, p-GSK3b, cytochrome c, caspase-
3, and PARP. Because H2O2 triggers caspases activation,
this study examined whether astaxanthin can inhibit caspases
activation in H2O2-treated mNPCs. After H2O2 treatment,
caspases activities were prominently increased, but astaxanthin
pretreatment significantly inhibited H2O2-mediated caspases
activation. Astaxanthin pretreatment also significantly
recovered the ATP production ability of H2O2-treated cells.
These findings indicate that astaxanthin inhibits H2O2-
mediated apoptotic features in mNPCs. Inhibition assays
with SB203580 (10 μM, a specific inhibitor of p38) and
PD98059 (10 μM, a specific inhibitor of MEK) clearly showed
that astaxanthin can inhibit H2O2-mediated apoptotic death
via modulation of p38 and MEK signaling pathways.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Andrew, A. G. / 1976 / Carotenoids of Phaffia rhodozyma, a red pigmented fermenting yeast / Phytochemistry 15 : 1003 ~ 1007
Bellavite, P. / 1988 / The superoxide-forming enzymatic system of phagocytes / Free Radical Biol. Med 4 : 225 ~ 261
Bendich, A. / 1989 / Biological actions of carotenoids / FASEB J 3 : 1927 ~ 1932
Bruce-Keller, A. J. / 1998 / Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid B-peptide / J. Neu
Cornett, C. R. / 1998 / Imbalances of the trace elements related to oxidative damage in Alzheimer disease brain / Neurotoxicology 19 : 339 ~ 345
Bellavite, P. / 1988 / The superoxide-forming enzymatic system of phagocytes / Free Radical Biol. Med 4 : 225 ~ 261
Bendich, A. / 1989 / Biological actions of carotenoids / FASEB J 3 : 1927 ~ 1932
Bruce-Keller, A. J. / 1998 / Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid B-peptide / J. Neu
Cornett, C. R. / 1998 / Imbalances of the trace elements related to oxidative damage in Alzheimer disease brain / Neurotoxicology 19 : 339 ~ 345
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