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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 2017.1
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DNA methylation is a stable epigenetic mark that can be inherited through multiple cell divisions. During development and cell differentiation, DNA methylation is dynamic, but some DNA methylation patterns may be retained as a form of epigenetic memory. DNA methylation profiles can be useful for the lineage classification and quality control of stem cells such as embryonic stem cells, induced pluripotent cells and mesenchymal stem cells. During cancer initiation and progression, genomewide and gene-specific DNA methylation changes occur as a consequence of mutated or deregulated chromatin regulators. Early aberrant DNA methylation states occurring during transformation appear to be retained during tumor evolution. Similarly, DNA methylation differences among different regions of a tumor reflect the history of cancer cells and their response to the tumor microenvironment. Therefore, DNA methylation can be a useful molecular marker for cancer diagnosis and drug treatment.
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참고문헌 (28)
참고문헌 신청
Arita K / 2008 / Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism / Nature 455 : 818 ~ 821
Barau J / 2016 / The DNA methyltransferase DNMT3C protects male germ cells from transposon activity / Science 354 : 909 ~ 912
Baylin SB / 2016 / Epigenetic determinants of cancer / Cold Spring Harb Perspect Biol 8 : a019505 ~
Bernstein BE / 2007 / The mammalian epigenome / Cell 128 : 669 ~ 681
Bird A / 2002 / DNA methylation patterns and epigenetic memory / Genes Dev 16 : 6 ~ 21
Barau J / 2016 / The DNA methyltransferase DNMT3C protects male germ cells from transposon activity / Science 354 : 909 ~ 912
Baylin SB / 2016 / Epigenetic determinants of cancer / Cold Spring Harb Perspect Biol 8 : a019505 ~
Bernstein BE / 2007 / The mammalian epigenome / Cell 128 : 669 ~ 681
Bird A / 2002 / DNA methylation patterns and epigenetic memory / Genes Dev 16 : 6 ~ 21
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