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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Genome-wide DNA methylation change is one of the major epigenetic regulation mechanisms involved in DNA damage response (DDR) and genome stability. Whole-genome bisulfite sequencing analysis demonstrated genomic DN A hypomethylation in all Arabidopsis genomes after gamma irradiation, but preferentially at non-CG sites of nuclear chromosomes. Chloroplastic or mitochondrial genome was the most resistant or the most sensitive to DNA hypomethylation induced by gamma irradiation, respectively. The methylation changes of those genomes displayed no difference between CG and non-CG sites. In contrast, the genomic DNA hypomethylation of nuclear chromosomes slightly differed depending on the gene regions or genomic features. The number of differentially methylated regions (DMRs) with decreased DNA methylation was much more than that of DMRs with increased DNA methylation in accordance with the overall DNA hypomethylaton of the whole genomes. Thirty-four DMRs were identified to be associated with transcriptome changes after gamma irradiation, but none of them were correlated with transcriptional induction of DDR genes. These results suggest that the genomewide DNA hypomethylation would play a role in indirect DDR mechanisms rather than in direct transcriptional activation for DDR genes.
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참고문헌 (12)
참고문헌 신청
Armstrong C / 2012 / DNMTs are required for delayed genome instability caused by radiation / Epigenetics 7:892~902
Boyko A / 2011 / Genome instability and epigenetic modification - heritable responses to environmental stress / Curr. Opin. Plant Biol 14:1~7
Chinnusamy V / 2009 / Epigenetic regulation of stress responses in plants / Curr. Opin. Plant Biol 12:133~139
Huumonen K / 2014 / Role of microRNAs and DNA methyltransferases in transmitting induced genomic instability between cell generations / Front. Public Health 2:139
Kim JE / 2013 / Characterization of non-CG genomic hypomethylation associated with gamma-ray-induced suppression of CMT3 transcription in Arabidopsis thaliana / Radiat. Res 180:638~648
Boyko A / 2011 / Genome instability and epigenetic modification - heritable responses to environmental stress / Curr. Opin. Plant Biol 14:1~7
Chinnusamy V / 2009 / Epigenetic regulation of stress responses in plants / Curr. Opin. Plant Biol 12:133~139
Huumonen K / 2014 / Role of microRNAs and DNA methyltransferases in transmitting induced genomic instability between cell generations / Front. Public Health 2:139
Kim JE / 2013 / Characterization of non-CG genomic hypomethylation associated with gamma-ray-induced suppression of CMT3 transcription in Arabidopsis thaliana / Radiat. Res 180:638~648
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