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Objectives: Medical students suffer from mental health and academic problems due to academicstress. We investigated academic stress and exhaustion along with psychological issues caused bymedical education during the years in the School of Korean Medicine. Methods: Two hundred fifty-one university students from the School of Korean Medicine, PusanNational University, were asked to complete the Medical Stress Scale (MSS), Maslach BurnoutInventory-Student Survey (MBI-SS), Positive Affect and Negative Affect Schedule (PANAS), andState-Trait Anxiety Inventory (STAI) three times during each semester for two years from 2013onwards. We analyzed the influence of school term and vacation on educational stress and negativeaffect with the T-test. The Pearson’s correlation analysis and regression analysis were used to predictchanges during the first semester or first years of study in the School of Korean Medicine. Results: Academic stress and burnout increased steadily until the first semester of third grade, whichwas measured with MSS and MBI-SS. The anxiety level was highest when the students started the firstgrade and it decreased significantly after the first semester. Negative affect repeatedly increased significantlyafter each school term; however, it reduced after each vacation. In the first grade, 19.5% ofthe last measure of MSS can be explained with the first measure of MSS. Discussion: This study extensively reviewed the trends and characteristics of four years of academicstress and its related psychological influence, and discussed its importance for developing a more efficientacademic curriculum for traditional Korean Medicine.

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