지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, and exhibitsdinucleotide hydrolase activity via a histidine triad motif. HITs are divided into five classes that have various functionsincluding galactose metabolism, DNA repair, and tumor suppression. Although multiple crystal structures have beenreported, limited structural information is available for HINT proteins of fungal species. In this study, to understand thestructural features and functional diversity of HINT proteins, we crystallized HINT from four fungal species and obtainedX-ray diffraction data from the pathogenic fungus Candida albicans at a resolution of 2.5 Å. The crystal of the C. albicansHINT (CaHINT) belonged to the space group of P2221, with unit cell parameters a = 40.4, b = 101.9, c = 175.2 Å, α = β = γ =90°. The crystal contained four macromolecules in asymmetric units.
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참고문헌 (16)
참고문헌 신청
Adams, P. D / 2010 / PHENIX : a comprehensive Python-based system for macromolecular structure solution / Acta Crystallogr D Biol Crystallogr 66:213~221
Bardaweel, S / 2010 / Probing the impact of the echinT C-terminal domain on structure and catalysis / J Mol Biol 404:627~638
Brenner, C / 2002 / Hint, Fhit, and GalT : function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases / Biochemistry 41:9003~9014
Butland, G / 2005 / Interaction network containing conserved and essential protein complexes in Escherichia coli / Nature 433:531~537
Chou, T. F / 2007 / Evidence that human histidine triad nucleotide binding protein 3(Hint3)is a distinct branch of the histidine triad(HIT)superfamily / J Mol Biol 373:978~989
Bardaweel, S / 2010 / Probing the impact of the echinT C-terminal domain on structure and catalysis / J Mol Biol 404:627~638
Brenner, C / 2002 / Hint, Fhit, and GalT : function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases / Biochemistry 41:9003~9014
Butland, G / 2005 / Interaction network containing conserved and essential protein complexes in Escherichia coli / Nature 433:531~537
Chou, T. F / 2007 / Evidence that human histidine triad nucleotide binding protein 3(Hint3)is a distinct branch of the histidine triad(HIT)superfamily / J Mol Biol 373:978~989
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