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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 598 - 603 (6page)
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초록· 키워드
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Purpose: CD93 is receiving renewed attention as a biomarker of inflammation. We aimed to evaluate the potential for serum sCD93 to serve as a novel biomarker for allergic inflammation.
Materials and Methods: We enrolled 348 subjects with an allergic disease [allergic rhinitis (AR), chronic spontaneous urticaria (CSU), or bronchial asthma (BA)], including 14 steroid-naïve BA patients who were serially followed-up.
Results: The serum sCD93 levels (ng/mL) in patients with exacerbated AR (mean±standard deviation, 153.1±58.4) were significantlyhigher than in patients without AR (132.2±49.0) or with stable AR (122.3±42.1). Serum sCD93 levels in exacerbated CSU (169.5±42.8) were also significantly higher than those in non-CSU (132.4±51.6) and stable CSU (122.8±36.2). This trend was also seen in BA. Serum levels in patients with ICS-naïve BA (161.4±53.1) were significantly higher than those in healthy controls withoutBA (112.2±30.8), low- and medium-dose ICS users. Serum sCD93 levels in high-dose ICS users (72.2±20.6) were significantly lower than those in low- and medium-dose users. The serum sCD93 levels in steroid-naïve patients with BA (195.1±72.7) decreasedafter ICS use for 4 weeks (134.4±42.8) and 8 weeks (100.7±13.4), serially.
Conclusion: Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU, AR, and asthma. ICS use significantly diminished serum sCD93 levels in steroid-naïve patients with BA. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Baines KJ / 2009 / The nutrigenomics of asthma:molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal / OMICS 13 : 355 ~ 365
Bandyopadhyay A / 2013 / Usefulness of induced sputum eosinophil count to assess severity and treatment outcome in asthma patients / Lung India 30 : 117 ~ 123
Bateman ED / 2008 / Global strategy for asthma management and prevention:GINA executive summary / Eur Respir J 31 : 143 ~ 178
Bielory L / 2013 / An algorithm for the management of allergic conjunctivitis / Allergy Asthma Proc 34 : 408 ~ 420
Boulet LP / 2015 / The revised 2014 GINA strategy report: opportunities for change / Curr Opin Pulm Med 21 : 1 ~ 7
Bandyopadhyay A / 2013 / Usefulness of induced sputum eosinophil count to assess severity and treatment outcome in asthma patients / Lung India 30 : 117 ~ 123
Bateman ED / 2008 / Global strategy for asthma management and prevention:GINA executive summary / Eur Respir J 31 : 143 ~ 178
Bielory L / 2013 / An algorithm for the management of allergic conjunctivitis / Allergy Asthma Proc 34 : 408 ~ 420
Boulet LP / 2015 / The revised 2014 GINA strategy report: opportunities for change / Curr Opin Pulm Med 21 : 1 ~ 7
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