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논문 기본 정보

자료유형
학술저널
저자정보
Huang Yue-ping (Department of Gerontological Neurology Heilongjiang Provincial Hospital) Xue Ju-jun (Department of Gerontological Neurology Heilongjiang Provincial Hospital) Li Chao (Department of Neurology Hongqi Hospital Mudanjiang Medical College) Chen Xi (Department of Experimental Diagnosis Heilongjiang Provincial Hospital) Fu Hong-juan (Department of Gerontological Neurology Heilongjiang Provincial Hospital) Fei Teng (Department of Experimental Diagnosis Heilongjiang Provincial Hospital) Bi Peng-xiang (Department of Neurology Hongqi Hospital Mudanjiang Medical College)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제17권 제9호
발행연도
2020.1
수록면
858 - 864 (7page)

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Objective To evaluate the associative role of depression and apolipoprotein E epsilon 4 allele (APOEε4) in subjective cognitive decline (SCD) and its progression to objective cognitive decline.Methods After literature search in electronic databases, studies were selected by following precise eligibility criteria. Meta-analyses were performed to examine the role of APOEε4 and depression in SCD or its progression to mild cognitive impairment (MCI) or dementia.Results APOEε4 positivity was not different between SCD and normal individuals but was significantly higher in individuals with SCD plus than in normal individuals [odds ratio: 2.39 (95% CI: 1.87, 3.05); p<0.00001] and in SCD converters than in non-converters [odds ratio: 5.19 (95% CI: 2.36, 11.42); p<0.00001]. Depression was significantly higher in individuals with SCD [standardized mean difference: 0.63 (0.45, 0.82); p<0.00001] and SCD plus [standardized mean difference: 0.83 (0.43, 1.22); p<0.0001] than in normal individuals. However, depression was not different between SCD and MCI or between SCD converters and non-converters. Age of SCD converters was higher than non-converters [mean difference: 2.95 years (0.58, 5.31)].Conclusion Whereas APOEε4 positivity was higher in SCD plus and SCD converters, depression was higher in SCD and SCD plus but was not different between SCD and MCI.

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