지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.8
- 수록면
- 231 - 235 (5page)
- DOI
- 10.5021/ad.24.020
이용수
초록· 키워드
오류제보하기
Background: There have been reports indicating a correlation between heightened intestinal permeability and many autoimmune and chronic inflammator y disorders. The involvement of autoimmunity is now recognized as a significant factor in the development of chronic spon- taneous urticaria (CSU). Zonulin is an important biomarker that regulates tight junction per- meability within cells in the gastrointestinal tract, hence facilitating intestinal permeability.
Objective: To evaluate the correlation of CSU with intestinal permeability by measuring the serum levels of zonulin in patients diagnosed with CSU.
Methods: The study included 60 patients diagnosed with CSU and 64 age- and sex-matched healthy individuals as controls. Levels of serum zonulin were determined using the ELISA method.
Results: Although the serum zonulin value of the patients was higher compared to the con- trols, the difference did not reach a significant level (24.65±8.49 ng/ml vs. 21.03±7.36 ng/ml, p=0.077). The serum zonulin level had a significant correlation with the urticaria activity score in the CSU group (p=0.013). The results of the current study revealed that serum zonulin values significantly differed between patients with CSU and healthy controls.
Conclusion: This study is important in terms of being the first to investigate the serum zonulin levels in CSU. However, there is a need for further studies with larger patient groups.
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