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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,461 - 1,467 (7page)
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초록· 키워드
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Purpose: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects and contributes to cellular proliferation and differentiation in the CNS. Recent studies have elucidated the function of microRNA let-7a (let-7a) as a regulator of cell differentiationwith roles in regulating genes associated with CNS neurogenesis.
Materials and Methods: This study aimed to investigate whether agmatine modulates the expression of crucial regulators of NSC differentiation including DCX, TLX, c-Myc, and ERK by controlling let-7a expression.
Results: Our data suggest that high levels of let-7a promoted the expression of TLX and c-Myc, as well as repressed DCX and ERK expression. In addition, agmatine attenuated expression of TLX and increased expression of ERK by negatively regulating let-7a.
Conclusion: Our study therefore enhances the present understanding of the therapeutic potential of NSCs in CNS disorders.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Yao J / 2012 / Neural stem cells: mechanisms and modeling / Protein Cell 3:251~261
Ming GL / 2011 / Adult neurogenesis in the mammalian brain:significant answers and significant questions / Neuron 70:687~702
Kazanis I / 2008 / The neural stem cell microenvironment / StemBook
Joo KM / 2013 / Experimental and clinical factors influencing long-term stable in vitro expansion of multipotent neural cells from human adult temporal lobes / Exp Neurol 240:168~177
Doetsch F / 2003 / A niche for adult neural stem cells / Curr Opin Genet Dev 13:543~550
Ming GL / 2011 / Adult neurogenesis in the mammalian brain:significant answers and significant questions / Neuron 70:687~702
Kazanis I / 2008 / The neural stem cell microenvironment / StemBook
Joo KM / 2013 / Experimental and clinical factors influencing long-term stable in vitro expansion of multipotent neural cells from human adult temporal lobes / Exp Neurol 240:168~177
Doetsch F / 2003 / A niche for adult neural stem cells / Curr Opin Genet Dev 13:543~550
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