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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 93 - 100 (8page)
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초록· 키워드
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Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In mammals, especially humans, a proper neurovascular unit comprising endothelial cells, pericytes, astrocytes, microglia, and neurons is essential for the homeostasis and survival of the central nervous system (CNS). In addition, the regeneration of neurovascular systems from neural stem cells and endothelial precursor cells after CNS diseases is responsible for functional repair. This review focused on the possible role of CO/HO in the neurovascular unit in terms of neurogenesis, angiogenesis, and synaptic plasticity, ultimately leading to behavioral changes in CNS diseases. CO/HO may also enhance cellular networks among endothelial cells, pericytes, astrocytes, and neural stem cells. This review highlights the therapeutic effects of CO/HO on CNS diseases involved in neurogenesis, synaptic plasticity, and angiogenesis. Moreover, the cellular mechanisms and interactions by which CO/HO are exploited for disease prevention and their therapeutic applications in traumatic brain injury, Alzheimer's disease, and stroke are also discussed.
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참고문헌 (82)
참고문헌 신청
Ahmad, A. S. / 2006 / Heme oxygenase-1 protects brain from acute excitotoxicity / Neuroscience 141:1703~1708
Almeida, A. S. / 2016 / Carbon Monoxide Releasing Molecule-A1 (CORM-A1) improves neurogenesis: increase of neuronal differentiation yield by preventing cell death / PLoS ONE 11:e0154781
Araque, A. / 2008 / Astrocytes process synaptic information / Neuron Glia Biol 4:3~10
Argaw, A. T. / 2012 / Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease / J. Clin. Invest. 122:2454~2468
Armulik, A. / 2010 / Pericytes regulate the blood-brain barrier / Nature 468:557~561
Almeida, A. S. / 2016 / Carbon Monoxide Releasing Molecule-A1 (CORM-A1) improves neurogenesis: increase of neuronal differentiation yield by preventing cell death / PLoS ONE 11:e0154781
Araque, A. / 2008 / Astrocytes process synaptic information / Neuron Glia Biol 4:3~10
Argaw, A. T. / 2012 / Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease / J. Clin. Invest. 122:2454~2468
Armulik, A. / 2010 / Pericytes regulate the blood-brain barrier / Nature 468:557~561
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