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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제1호
- 발행연도
- 2016.1
- 수록면
- 41 - 51 (11page)
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Adult hippocampal dentate granule neurons are generated from neural stem cells (NSCs) in the mammalian brain, and the fate specification of adult NSCs is precisely controlled by the local niches and environment, such as the subventricular zone (SVZ), dentate gyrus (DG), and Toll-like receptors (TLRs). Epigallocatechin-3-gallate (EGCG) is the main polyphenolic flavonoid in green tea that has neuroprotective activities, but there is no clear understanding of the role of EGCG in adult neurogenesis in the DG after neuroinflammation. Here, we investigate the effect and the mechanism of EGCG on adult neurogenesis impaired by lipopolysaccharides (LPS). LPS-induced neuroinflammation inhibited adult neurogenesis by suppressing the proliferation and differentiation of neural stem cells in the DG, which was indicated by the decreased number of Bromodeoxyuridine (BrdU)-, Doublecortin (DCX)- and Neuronal Nuclei (NeuN)-positive cells. In addition, microglia were recruited with activatingTLR4-NF-κB signaling in the adult hippocampus by LPS injection. Treating LPS-injured mice with EGCG restored the proliferation and differentiation of NSCs in the DG, which were decreased by LPS, and EGCG treatment also ameliorated the apoptosis of NSCs. Moreover, pro-inflammatory cytokine production induced by LPS was attenuated by EGCG treatment through modulating the TLR4-NF-κB pathway. These results illustrate that EGCG has a beneficial effect on impaired adult neurogenesis caused by LPSinduced neuroinflammation, and it may be applicable as a therapeutic agent against neurodegenerative disorders caused by inflammation.
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참고문헌 (55)
참고문헌 신청
Ekdahl CT / 2009 / Brain inflammation and adult neurogenesis: the dual role of microglia / Neuroscience 158:1021~1029
Polazzi E / 2010 / Microglia and neuroprotection: from in vitro studies to therapeutic applications / Prog Neurobiol 92:293~315
Dheen ST / 2007 / Microglial activation and its implications in the brain diseases / Curr Med Chem 14:1189~1197
Lourbopoulos A / 2015 / Microglia in action: how aging and injury can change the brain's guardians / Front Cell Neurosci 9:54
Casano AM / 2015 / Microglia: multitasking specialists of the brain / Dev Cell 32:469~477
Polazzi E / 2010 / Microglia and neuroprotection: from in vitro studies to therapeutic applications / Prog Neurobiol 92:293~315
Dheen ST / 2007 / Microglial activation and its implications in the brain diseases / Curr Med Chem 14:1189~1197
Lourbopoulos A / 2015 / Microglia in action: how aging and injury can change the brain's guardians / Front Cell Neurosci 9:54
Casano AM / 2015 / Microglia: multitasking specialists of the brain / Dev Cell 32:469~477
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