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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 943 - 952 (10page)
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초록· 키워드
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Traumatic brain injury (TBI) is associated with poor neurological outcome, including necrosis and brain edema. In this study, we investigated whether agmatine treatment reduces edema and apoptotic cell death after TBI. TBI was produced by cold injury to the cerebral primary motor cortex of rats. Agmatine was administered 30 min after injury and once daily until the end of the experiment. Animals were sacrificed for analysis at 1, 2, or 7 days after the injury. Various neurological analyses were performed to investigate disruption of the blood-brain barrier (BBB) and neurological dysfunction after TBI. To examine the extent of brain edema after TBI, the expression of aquaporins (AQPs), phosphorylation of mitogen-activated protein kinases (MAPKs), and nuclear translocation of nuclear factor-κB (NF-κB) were investigated. Our findings demonstrated that agmatine treatment significantly reduces brain edema after TBI by suppressing the expression of AQP1, 4, and 9. In addition, agmatine treatment significantly reduced apoptotic cell death by suppressing the phosphorylation of MAPKs and by increasing the nuclear translocation of NF-κB after TBI. These results suggest that agmatine treatment may have therapeutic potential for brain edema and neural cell death in various central nervous system diseases.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Reilly PL / 2001 / Brain injury: the pathophysiology of the first hours.’Talk and Die revisited’ / J Clin Neurosci 8:398~403
McIntosh TK / 1998 / Novel pharmacologic strategies in the treatment of experimental traumatic brain injury : 1998 / J Neurotrauma 15:731~769
Murakami K / 1999 / Cold injury in mice : a model to study mechanisms of brain edema and neuronal apoptosis / Prog Neurobiol 57:289~299
Hu BR / 2000 / Alteration of MAP kinase pathways after transient forebrain ischemia / J Cereb Blood Flow Metab 20:1089~1095
Sugino T / 2000 / Activation of mitogen-activated protein kinases in gerbil hippocampus with ischemic tolerance induced by 3-nitropropionic acid / Neurosci Lett 278:101~104
McIntosh TK / 1998 / Novel pharmacologic strategies in the treatment of experimental traumatic brain injury : 1998 / J Neurotrauma 15:731~769
Murakami K / 1999 / Cold injury in mice : a model to study mechanisms of brain edema and neuronal apoptosis / Prog Neurobiol 57:289~299
Hu BR / 2000 / Alteration of MAP kinase pathways after transient forebrain ischemia / J Cereb Blood Flow Metab 20:1089~1095
Sugino T / 2000 / Activation of mitogen-activated protein kinases in gerbil hippocampus with ischemic tolerance induced by 3-nitropropionic acid / Neurosci Lett 278:101~104
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