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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 67 - 76 (10page)
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초록· 키워드
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Background: Sepsis-induced cardiomyopathy (SIC) occurs frequently in critically ill patients, but the clinical features and prognostic impact of SIC on sepsis outcome remain controversial. Here, we investigated the predictors and outcomes of SIC. Methods: Patients admitted to a single medical intensive care unit from June 2016 to September 2017 were retrospectively reviewed. SIC was diagnosed by ejection fraction (EF) <50% and ≥10% decrease in baseline EF that recovered within 2 weeks. Results: In total, 342 patients with sepsis met the inclusion criteria, and 49 patients (14.3%) were diagnosed with SIC; the latter were compared with 259 patients whose EF was not deteriorated by sepsis (non-SIC). Low systolic blood pressure and increased left ventricular enddiastolic diameter (LVEDD) were identified as predictors of SIC. SIC and non-SIC patients did not differ significantly in terms of 28-day all-cause mortality (24.5% vs. 26.3%, P=0.936). Acute Physiology and Chronic Health Evaluation II (APACHE II; hazard ratio [HR], 1.10; 95% confidential interval [CI], 1.02 to 1.18; P=0.009) and delta neutrophil index (DNI; HR, 1.02; 95% CI, 1.00 to 1.08; P=0.026) were independent risk factors for 28-day mortality with SIC. DNI, APACHE II, and lactate were identified as risk factors for 28-day mortality in sepsis patients as a whole. Conclusions: SIC was not associated with increased mortality compared to non-SIC. Low systolic blood pressure and increased LVEDD were predictors of SIC. High APACHE II score and elevated DNI, which reflect sepsis severity, predict 28-day all-cause mortality.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Singer M / 2016 / The Third International Consensus Definitions for Sepsis and Septic Shock(Sepsis-3) / JAMA 315:801~810
Parker MM / 1984 / Profound but reversible myocardial depression in patients with septic shock / Ann Intern Med 100:483~490
Jardin F / 1990 / Sepsis-related cardiogenic shock / Crit Care Med 18:1055~1060
Etchecopar-Chevreuil C / 2008 / Cardiac morphological and functional changes during early septic shock : a transesophageal echocardiographic study / Intensive Care Med 34:250~256
Vieillard-Baron A / 2008 / Actual incidence of global left ventricular hypokinesia in adult septic shock / Crit Care Med 36:1701~1706
Parker MM / 1984 / Profound but reversible myocardial depression in patients with septic shock / Ann Intern Med 100:483~490
Jardin F / 1990 / Sepsis-related cardiogenic shock / Crit Care Med 18:1055~1060
Etchecopar-Chevreuil C / 2008 / Cardiac morphological and functional changes during early septic shock : a transesophageal echocardiographic study / Intensive Care Med 34:250~256
Vieillard-Baron A / 2008 / Actual incidence of global left ventricular hypokinesia in adult septic shock / Crit Care Med 36:1701~1706
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