지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 170 - 175 (6page)
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초록· 키워드
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Purpose : FSGS do not respond well to any kind of therapy and gradually progress to end-stage renal disease. This study was conducted to investigate the difference of protein expression between MCNS and FSGS as a preliminary study for understanding the pathophysiology of FSGS.
Methods : Renal biopsy samples of MCNS and FSGS were obtained, which was diagnosed by one pathologist. They were solubilized with a conventional extraction buffer for protein extraction. The solution was applied on immobilized linear gradient strip gel (pH 4-7) using IPGphor system. Silver staining was carried out according to standard method. Protein identification was done by searching NCBI database using MASCOT Peptide Mass Fingerprint software.
Results : The differences in protein expressions between MCNS and FSGS were shown by increased or decreased protein spots. Most prominently expressed spot among several spots in FSGS was isolated and analyzed, one of which was glutathione S-transferase (GST) P1-1, whereas it was not found in MCNS. So GSTP1-1 was considered as the one of the key biomarkers in pathogenesis of FSGS.
Conclusion : This result would be helpful in diagnosing FSGS and researching FSGS. Further studies for glutathione S-transferase P1-1 might be necessary to elucidate the mechanisms regarding FSGS.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Chew SL / 1993 / Urinary enzymes in acute renal failure / Nephrol Dial Transplant 8 : 507 ~ 511
Cullen KJ / 2003 / Glutathione s-transferase pi amplification is associated with cisplatin resistance in head and neck squamous cell carcinoma cell lines and primary tumors /
Cutillas P / 2004 / Proteomic strategies and their application in studies of renal function / News Physiol Sci 19 : 114 ~ 119
Eddy AA / 2003 / Nephrotic syndrome in childhood / Lancet 362 : 629 ~ 639
Filler G / 2003 / Is there really an increase in non-minimal change nephrotic syndrome in children? / Am J Kidney Dis 42 : 1107 ~ 1113
Cullen KJ / 2003 / Glutathione s-transferase pi amplification is associated with cisplatin resistance in head and neck squamous cell carcinoma cell lines and primary tumors /
Cutillas P / 2004 / Proteomic strategies and their application in studies of renal function / News Physiol Sci 19 : 114 ~ 119
Eddy AA / 2003 / Nephrotic syndrome in childhood / Lancet 362 : 629 ~ 639
Filler G / 2003 / Is there really an increase in non-minimal change nephrotic syndrome in children? / Am J Kidney Dis 42 : 1107 ~ 1113
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