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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 87 - 92 (6page)
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Porcine edema disease (ED) is a communicable disease of pigs caused by infection with Shiga toxin (Stx)-producing Escherichia coli (STEC) which expresses F18 fimbriae and/or Stx type 2e (Stx2e). While STEC causes a severe illness including hemorrhagic colitis and hemolytic-uremic syndrome in humans, it induces damage to the vascular endothelium, which results in edema, hemorrhage, and micro-thrombosis, leading in high mortality in pigs. In the present study, we cultured Stx2e-producing E. coli field isolates from conventional pig farms that experienced sudden deaths previously with symptoms similar to porcine edema disease, which were further investigated with Shiga toxin profiles. A total of 43 strains were identified from the collected samples by F18 or Stx2e specific PCR. Based on the PCR, 42 isolates out of 43 isolates were proved to carry one of F18 or Stx2e genes and 14 isolates to carry both F18 and Stx2e genes. All of the 30 isolates that harbored Stx2e gene induced the cytopathic effect (CPE) in vero cells and especially, the isolate 150229 produced the highest level of Shiga toxin. Therefore, we identified the virulence genes (F18 and Stx2e) and demonstrated Shiga toxin-producing abilities from porcine edema disease causing E. coli filed isolates. These results suggested that one of the isolates could be a vaccine antigen candidate against STEC through further investigating to elicit an immune response.
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참고문헌 (20)
참고문헌 신청
변재원 / 2015 / 돼지 부종병의 원인과 대책 / 월간한돈
Bertin Y / 2001 / Stx2subtyping of Shiga toxin-producing Escherichia coli isolated from cattle in France: detection of a new Stx2 subtype and correlation with additional virulence factors / J Clin Microbiol 39:3060~3065
Bettelheim KA / 2003 / Rapid laboratory identification and characterization of verocytotoxigenic (Shiga toxin producing) Escherichia coli (VETC/STEC) / J Appl Microbiol 95:205~217
조은정 / 2005 / 분리 대장균 O139의 Shigatoxin2e A 유전자의 효소 활성부에 대한 결손변이 유발 및 변이 단밸질의 발현 / 한국임상수의학회지 22(4):386~391
Cornick NA / 2000 / Shiga Toxin-Producing Escherichia coli Infection:Temporal and Quantitative Relationships among Coloni-zation, Toxin Production, and Systemic Disease / Journal of Infectious Diseases 181:242~251
Bertin Y / 2001 / Stx2subtyping of Shiga toxin-producing Escherichia coli isolated from cattle in France: detection of a new Stx2 subtype and correlation with additional virulence factors / J Clin Microbiol 39:3060~3065
Bettelheim KA / 2003 / Rapid laboratory identification and characterization of verocytotoxigenic (Shiga toxin producing) Escherichia coli (VETC/STEC) / J Appl Microbiol 95:205~217
조은정 / 2005 / 분리 대장균 O139의 Shigatoxin2e A 유전자의 효소 활성부에 대한 결손변이 유발 및 변이 단밸질의 발현 / 한국임상수의학회지 22(4):386~391
Cornick NA / 2000 / Shiga Toxin-Producing Escherichia coli Infection:Temporal and Quantitative Relationships among Coloni-zation, Toxin Production, and Systemic Disease / Journal of Infectious Diseases 181:242~251
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