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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.3
- 수록면
- 39 - 42 (4page)
- DOI
- http://dx.doi.org/10.13041/jpvm.2017.41.1.39
이용수
초록· 키워드
오류제보하기
As a food-borne zoonotic bacterial pathogen, Shiga toxin-producing Escherichia coli (STEC) cause many diseases including mild diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Among various virulence factors previously defined in STEC, Shiga toxins (Stxs) are the hallmark of all the STEC isolates although their expression levels are varied by strains. In this study, we developed a high-affinity monoclonal antibody (mAb) against Stx type 1 (Stx1) produced by STEC.
Through searching for the immuno-dominant epitopes in the A subunit of Stx1, two mAb clones specific to Stx1 (designated as 3E3 and 4D4) were selected and evaluated for their specificity and sensitivity. Our results demonstrated that those mAbs were highly specific to Stx1 and sensitive 4 times more than the commercially-available Stx1 antibodies.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Allison HE / 2007 / Stx-phages: drivers and mediators of the evolution of STEC and STEC-like pathogens / Future Microbiol 2:165~174
Cantey JR / 1985 / Shiga toxin--an expanding role in the pathogenesis of infectious diseases / J Infect Dis 151:766~771
Fratamico PM / 2014 / Evaluation of a multiplex real-time PCR method for detecting shiga toxin-producing Escherichia coli in beef and comparison to the U.S. Department of Agriculture Food Safety and Inspection Service Microbiology laboratory guidebook method / J Food Prot 77:180~188
Harris JR / 1999 / Keyhole limpet hemocyanin (KLH):a biomedical review / Micron 30:597~623
Hussein HS / 2008 / Growth and enrichment medium for detection and isolation of Shiga toxin-producing Escherichia coli in cattle feces / J Food Prot 71:927~933
Cantey JR / 1985 / Shiga toxin--an expanding role in the pathogenesis of infectious diseases / J Infect Dis 151:766~771
Fratamico PM / 2014 / Evaluation of a multiplex real-time PCR method for detecting shiga toxin-producing Escherichia coli in beef and comparison to the U.S. Department of Agriculture Food Safety and Inspection Service Microbiology laboratory guidebook method / J Food Prot 77:180~188
Harris JR / 1999 / Keyhole limpet hemocyanin (KLH):a biomedical review / Micron 30:597~623
Hussein HS / 2008 / Growth and enrichment medium for detection and isolation of Shiga toxin-producing Escherichia coli in cattle feces / J Food Prot 71:927~933
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