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Shiga toxin 2e (Stx2e) has a pivotal role in the colonization and enterotoxicity of F18+Shiga toxin-producing Escherichia coli (STEC), which causes porcine edema disease (ED). In this study, a Stx2eA mutant, which has a Glu167Gln mutation in Stx2eA that inactivates N-glycosidase activity, was genetically engineered to evaluate its potential immunogenicity and protective efficacy. A significant increase in serum IgG1 (a Th2 indicator) was shown in mice immunized with the mutated Stx2eA. However, only 56% of the mice immunized with the toxoid (5 μg) survived following a challenge with a lethal dose 50 (LD50) of a virulent F18+STEC strain (JOL654), while mice immunized with Salmonella ghosts delivering selected antigens of F18+STEC showed an 86% survival rate. The results suggest that sole use of the mutated Stx2eA toxoid may not be an effective preventive strategy for the control of porcine ED.
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참고문헌 (13)
참고문헌 신청
Duan Q / 2013 / Contribution of flagellin subunit FliC to piglet epithelial cells invasion by F18ab E. coli / Vet Microbiol 166:220~224
Fekete PZ / 2002 / Replicon typing of F18 fimbriae encoding plasmids of enterotoxigenic and verotoxigenic Escherichia coli strains from porcine postweaning diarrhoea and oedema disease / Vet Microbiol 85:275~284
Gordon VM / 1992 / An enzymatic mutant of Shiga-like toxin II variant is a vaccine candidate for edema disease of swine / Infect Immun 60:485~490
Hur J / 2015 / A new enterotoxigenic Escherichia coli vaccine candidate constructed using a Salmonella ghost delivery system: Comparative evaluation with a commercial vaccine for neonatal piglet colibacillosis / Vet Immunol Immunopathol 164:101~109
Marques LRM / 1987 / Escherichia coli strains isolated from pigs with edema disease produce a variant of Shiga-like toxin II / FEMS Microbiol Lett 44:33~38
Fekete PZ / 2002 / Replicon typing of F18 fimbriae encoding plasmids of enterotoxigenic and verotoxigenic Escherichia coli strains from porcine postweaning diarrhoea and oedema disease / Vet Microbiol 85:275~284
Gordon VM / 1992 / An enzymatic mutant of Shiga-like toxin II variant is a vaccine candidate for edema disease of swine / Infect Immun 60:485~490
Hur J / 2015 / A new enterotoxigenic Escherichia coli vaccine candidate constructed using a Salmonella ghost delivery system: Comparative evaluation with a commercial vaccine for neonatal piglet colibacillosis / Vet Immunol Immunopathol 164:101~109
Marques LRM / 1987 / Escherichia coli strains isolated from pigs with edema disease produce a variant of Shiga-like toxin II / FEMS Microbiol Lett 44:33~38
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