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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 28 - 39 (12page)
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초록· 키워드
오류제보하기
Persistent organic pollutants (POPs) can affect epigenetic mechanisms and obesity development. Polybrominated diphenyl ethers (PBDEs)-widely used to make flames-are one of the important POPs. Prenatal exposure to endocrine disrupting chemicals (EDCs), such as POPs, may affect global DNA methylation in long interspersed nuclear elements (LINE-1), increasing the risk of obesity later in life. Therefore, pregnant Sprague-Dawley (SD) rats were used to elucidate whether BDE-47 and BDE-209 transferred through placenta and breast milk cause epigenetic changes in LINE-1 and increase genetic susceptibility to obesity as obesogen during the developmental periods. Global DNA methylation in LINE-1 and gene expression related to obesity were measured in dams and offspring, using a methylation-sensitive high resolution melting analysis (MS-HRM) and direct bisulfite sequencing and quantitative real time polymerase chain reaction (qPCR), respectively. The results of MS-HRM showed global DNA hypomethylation patterns in LINE-1 of exposed offspring (2 of total 4) at PND 4, but bisulfite sequencing showed no difference in both the exposed and non-exposed groups. Gene expression in dams related to β-oxidation pathway and those related to adipokines showed different patterns between the two groups. On the contrary, gene expressions of offspring showed a similar pattern. Gene expressions related to β-oxidation pathway and obesity were significantly increased when compared with `at birth`, but not PPAR-α. In conclusion, this study demonstrated the possibility that co-exposure to BDE-47 and BDE-209- via the placenta and breast milk-may affect epigenetic changes and modulate gene expression levels related to obesity.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
An W / 2011 / Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs / Mob DNA 2 (1) : 2 ~
Aschebrook-Kilfoy B / 2015 / Polybrominated diphenyl ethers and thyroid cancer risk in the prostate, colorectal, lung, and ovarian cancer screening trial cohort / Am J Epidem
Beck CR / 2011 / LINE-1 elements in structural variation and disease / Annu Rev Genomics Hum Genet 12 : 187 ~ 215
Byun HM / 2015 / Epigenetic effects of low perinatal doses of flame retardant BDE-47 on mitochondrial and nuclear genes in rat offspring / Toxicology 328 : 152 ~ 159
Costa LG / 2008 / Polybrominated diphenyl ether (PBDE) flame retardants: environmental contamination, human body burden and potential adverse health effects / Acta Biomed : A
Aschebrook-Kilfoy B / 2015 / Polybrominated diphenyl ethers and thyroid cancer risk in the prostate, colorectal, lung, and ovarian cancer screening trial cohort / Am J Epidem
Beck CR / 2011 / LINE-1 elements in structural variation and disease / Annu Rev Genomics Hum Genet 12 : 187 ~ 215
Byun HM / 2015 / Epigenetic effects of low perinatal doses of flame retardant BDE-47 on mitochondrial and nuclear genes in rat offspring / Toxicology 328 : 152 ~ 159
Costa LG / 2008 / Polybrominated diphenyl ether (PBDE) flame retardants: environmental contamination, human body burden and potential adverse health effects / Acta Biomed : A
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