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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제21권 제3호
- 발행연도
- 2017.1
- 수록면
- 125 - 130 (6page)
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초록· 키워드
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Purpose: To evaluate the clinical significance of T1 high signal intensity on the globus pallidus as a predictor of severe hepatic encephalopathy in patients with acute-on-chronic liver failure (ACLF), which is a distinct syndrome characterized by multi-organ dysfunction including cerebral failure.
Materials and Methods: From January 2002 to April 2014, we retrospectively reviewed the magnetic resonance imaging (MRI) findings and clinical and magnetic resonance (MR) features of 74 consecutive patients (44 men and 30 women; mean age, 59.5 years) with liver cirrhosis. The chronic liver failure-sequential organ failure assessment score was used to diagnose ACLF. The pallidal index (PI), calculated by dividing the mean signal intensity of the globus pallidus by that of the subcortical frontal white matter were compared according to ACLF. The PI was compared with the Model for End-Stage Liver Disease (MELD) score in predicting the development of ACLF.
Results: Fifteen patients who were diagnosed with ACLF had higher hepatic encephalopathy grades (initial, P = 0.024; follow-up, P = 0.002), MELD scores (P < 0.001), and PI (P = 0.048). In the ACLF group, the mean PI in patients with cerebral failure was significantly higher than that in the patients without cerebral failure (1.33 vs. 1.20, P = 0.039). In patients with ACLF, the area under the curve (AUC) for PI was 0.680 (95% confidence intervals [CI], 0.52-0.85), which was significantly lower than that for the MELD score (AUC, 0.88; 95% CI, 0.77-0.99) (P = 0.04).
Conclusion: The PI can be an ancillary biomarker for predicting the development of ACLF and severe hepatic encephalopathy.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Arroyo V / 2015 / EASL-CLIF Consotrium CANONIC Study. Acute-on-chronic liver failure:A new syndrome that will re-classify cirrhosis / J Hepatol 62 : S131 ~ S143
Blei AT / 2001 / Practice Parameters Committee of the American College of Gastroenterology. Hepatic encephalopathy / Am J Gastroenterol 96 : 1968 ~ 1976
Burkhard PR / 2003 / Chronic parkinsonism associated with cirrhosis : a distinct subset of acquired hepatocerebral degeneration / Arch Neurol 60 : 521 ~ 528
Chang Y / 2010 / Pallidal index measured with three-dimensional T1-weighted gradient echo sequence is a good predictor of manganese exposure in welders / J Magn Reson Imaging
Criswell SR / 2012 / Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders / Occup Environ Med 69 : 437 ~ 443
Blei AT / 2001 / Practice Parameters Committee of the American College of Gastroenterology. Hepatic encephalopathy / Am J Gastroenterol 96 : 1968 ~ 1976
Burkhard PR / 2003 / Chronic parkinsonism associated with cirrhosis : a distinct subset of acquired hepatocerebral degeneration / Arch Neurol 60 : 521 ~ 528
Chang Y / 2010 / Pallidal index measured with three-dimensional T1-weighted gradient echo sequence is a good predictor of manganese exposure in welders / J Magn Reson Imaging
Criswell SR / 2012 / Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders / Occup Environ Med 69 : 437 ~ 443
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