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논문 기본 정보

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저자정보
Do Seon Song (Department of Internal Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Seoul) Hee Yeon Kim (Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea, Seoul) Young Kul Jung (Department of Internal Medicine, Korea University Ansan Hospital, Ansan) Tae Hyung Kim (Department of Internal Medicine, Korea University Ansan Hospital, Ansan) Hyung Joon Yim (Department of Internal Medicine, Korea University Ansan Hospital, Ansan) Eileen L. Yoon (Department of Internal Medicine, Hanyang University College of Medicine, Seoul; Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, Korea) Ki Tae Suk (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon) Jeong-ju Yoo (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon) Sang Gyune Kim (Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon) Moon Young Kim (Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea) Young Chang (Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul) Soung Won Jeong (Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul) Jae Young Jang (Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul) Sung-Eun Kim (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon) Jung-Hee Kim (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon) Jung Gil Park (Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea) Won Kim (Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea) Dong Joon Kim (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon) Ashok Kumar Choudhury (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) Vinod Arora (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India) Shiv Kumar Sarin (Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology Vol.30 No.3
발행연도
2024.7
수록면
388 - 405 (18page)

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Background/Aims: Quick sequential organ failure assessment (qSOFA) is believed to identify patients at risk of poor outcomes in those with suspected infection. We aimed to evaluate the ability of modified qSOFA (m-qSOFA) to identify high-risk patients among those with acutely deteriorated chronic liver disease (CLD), especially those with acute-on-chronic liver failure (ACLF). Methods: We used data from both the Korean Acute-on-Chronic Liver Failure (KACLiF) and the Asian Pacific Association for the Study of the Liver ACLF Research Consortium (AARC) cohorts. qSOFA was modified by replacing the Glasgow Coma Scale with hepatic encephalopathy, and an m-qSOFA ≥2 was considered high. Results: Patients with high m-qSOFA had a significantly lower 1-month transplant-free survival (TFS) in both cohorts and higher organ failure development in KACLiF than those with low m-qSOFA (Ps<0.05). Subgroup analysis by ACLF showed that patients with high m-qSOFA had lower TFS than those with low m-qSOFA. m-qSOFA was an independent prognostic factor (hazard ratios, HR=2.604, 95% confidence interval, CI 1.353–5.013, P=0.004 in KACLiF and HR=1.904, 95% CI 1.484–2.442, P<0.001 in AARC). The patients with low m-qSOFA at baseline but high m-qSOFA on day 7 had a significantly lower 1-month TFS than those with high m-qSOFA at baseline but low m-qSOFA on day 7 (52.6% vs. 89.4%, P<0.001 in KACLiF and 26.9% vs. 61.5%, P<0.001 in AARC). Conclusions: Baseline and dynamic changes in m-qSOFA may identify patients with a high risk of developing organ failure and short-term mortality among CLD patients with acute deterioration.
#qSOFA #Acute-on-chronic liver failure #Organ failure #Survival

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