지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제3권 제1호
- 발행연도
- 2010.1
- 수록면
- 18 - 23 (6page)
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초록· 키워드
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Objectives. While other cytokines are known to be associated with otitis media with effusion (OME), the involvement of heat shock protein 70 (HSP70) in middle ear effusion (MEE) is unknown. This study was undertaken to investigate the possibility of there being a HSP70 expression in human MEE and to determine its potential role as a cytokine in OME.
Methods. The levels of HSP70, tumor necrosis factor-alpha and interleukin-1beta were measured by enzyme-linked immunosorbent assay in the effusion of different groups of OME patient following collection of the MEE using our new collection system. The clinical characteristics of the OME patients and the MEE status were analyzed.
Results. HSP70 was expressed in all the types of MEE. The mucous and seromucous effusions showed higher HSP70 levels than that of the serous effusion. The HSP70 level was correlated with the levels of tumor necrosis factor (TNF)-a and interleukin (IL)-1b in the effusions. The positive correlations between HSP70, TNF-a and IL-1b were statistically significant (P<0.05).
Conclusion. The highly elevated level of HSP70 in the seromucous and mucous effusions implicates this protein in the chronicity of OME.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Bi AF / 2000 / HSP70 expression of middle ear mucosa in acute suppurative otitis media / Lin Chuang Er Bi Yan Hou Ke Za Zhi 14 (4) : 173 ~ 174
Egusa K / 1995 / Heat shock proteins in acute otitis media / Laryngoscope 105 (7 Pt 1) : 708 ~ 713
Hartl FU / 2002 / Molecular chaperones in the cytosol:from nascent chain to folded protein / Science 295 (5561) : 1852 ~ 1858
Hauser GJ / 1996 / HSP induction inhibits iNOS mRNA expression and attenuates hypotension in endotoxin- challenged rats / Am J Physiol 271 (6 Pt 2) : H2529 ~ H2535
Jang CH / 2002 / Characterization of cytokines present in pediatric otitis media with effusion:comparison of allergy positive and negative / Int J Pediatr Otorhinolaryngol 66
Egusa K / 1995 / Heat shock proteins in acute otitis media / Laryngoscope 105 (7 Pt 1) : 708 ~ 713
Hartl FU / 2002 / Molecular chaperones in the cytosol:from nascent chain to folded protein / Science 295 (5561) : 1852 ~ 1858
Hauser GJ / 1996 / HSP induction inhibits iNOS mRNA expression and attenuates hypotension in endotoxin- challenged rats / Am J Physiol 271 (6 Pt 2) : H2529 ~ H2535
Jang CH / 2002 / Characterization of cytokines present in pediatric otitis media with effusion:comparison of allergy positive and negative / Int J Pediatr Otorhinolaryngol 66
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