지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제2권 제3호
- 발행연도
- 2009.1
- 수록면
- 131 - 135 (5page)
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초록· 키워드
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Objectives. Inadequate antibody responses to pathogens may lead to the recurrence of otitis media with effusion (OME).
Although B-cell production by antibodies is controlled by transcription factors, the status of these factors has not been
assessed in patients with OME.
Methods. Expression of immunoglobulin was measured by enzyme-linked immunosorbent assay. Expression of transcription
factors Bcl-6, Blimp-1, Pax-5, and XBP-1 was assessed by RT-PCR in the middle-ear fluid of 29 children with >4
OME episodes in 12 months or >3 episodes in 6 months (the OME-prone group) and in 32 children with <3 OME
episodes in 12 months (OME group). The relationship between recurrence of OME and expression levels of immunoglobulins
and transcription factors in middle-ear fluid was determined.
Results. The concentration of IgA in middle-ear fluid was significantly lower in the OME-prone than in the OME group, as
was the expression of mRNA encoding the transcription factors Blimp-1 and XBP-1 (P<0.05 each). Expression of mRNA
encoding the transcription factors Bcl-6 and Pax-5 was more intense in the OME-prone than in the OME group, but
these differences were not significant (P>0.05).
Conclusion. Lower concentrations of IgA, Blimp-1 and XBP-1 in middle ear fluid of patients with OME may be related
to OME recurrence and chronicity.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Angelin-Duclos C / 2000 / Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo / J Immunol 165 (10) : 5462 ~ 5471
Bluestone CD / 1995 / Clinical practice guideline on otitis media with effusion in young children: strengths and weaknesses / Otolaryngol Head Neck Surg 112 (4) : 507 ~ 511
Cummings CW / 2005 / Cummings otolaryngology: head and neck surgery / Mosby Co
Freijd A / 1984 / Plasma anti-pneumococcal antibody activity of the IgG class and subclasses in otitis prone children / Clin Exp Immunol 56 (2) : 233 ~ 238
Howie VM / 1973 / Immunoglobulins of the middle ear fluid in acute otitis media: relationship to serum immunoglobulin concentrations and bacterial cultures / Infect Immun 7 (
Bluestone CD / 1995 / Clinical practice guideline on otitis media with effusion in young children: strengths and weaknesses / Otolaryngol Head Neck Surg 112 (4) : 507 ~ 511
Cummings CW / 2005 / Cummings otolaryngology: head and neck surgery / Mosby Co
Freijd A / 1984 / Plasma anti-pneumococcal antibody activity of the IgG class and subclasses in otitis prone children / Clin Exp Immunol 56 (2) : 233 ~ 238
Howie VM / 1973 / Immunoglobulins of the middle ear fluid in acute otitis media: relationship to serum immunoglobulin concentrations and bacterial cultures / Infect Immun 7 (
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