소아의 재발성 삼출성 중이염에서 세균과 항체와의 연관성

김상훈; 여승근; 신일호; 변재용; 박문서; 차창일

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자료유형: 학술저널

저자정보: 김상훈 여승근 신일호 변재용 박문서 차창일

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제11호

발행연도: 2008.1

수록면: 979 - 984 (6page)

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Upper respiratory infections and host immunity against infection may be important in the pathophysiology of otitis media effusion (OME) in children with as yet undeveloped Eustachian tubes. So, we measured Ig concentrations in effusion fluid and serum, and examined their relationship with the presence of bacteria in effusion fluid, as determined by the conventional culture methods and PCR. Subjects and Method：Middle ear effusion was collected from 61 OME patients who had undergone ventilation tube insertion. Bacteria in effusion fluid were detected by standard bacterial culture and polymerase chain reaction. Middle ear fluid immunoglobulins in the OME prone group and OME non-prone group were evaluated. Results：The level of IgA in the otits media prone group was significantly lower than in the otitis media non-prone group, but there was no significant difference in the level of IgG, IgM between two groups (p<0.05). Bacteria detection rate were 59% in the prone group and 50% in the non-prone group. The level of IgA in the bacterial detection group was signifi-cantly lower than that of the non-detection group (p<0.05). Conclusion：These results suggest that IgA seems to be important in the protection of bacterial growth and local immunity in the middle ear and may be related to the chronicity or relapse of OME. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:979-84)

#Otitis media·Immunoglobulins·Bacteria·Polymerase chain reaction.

참고문헌 (20)

참고문헌 신청

Arita M / 2003 / Single cell analysis of adenoid CD5+B cells and their protective contributions to nasopharyngeal immunity / Laryngoscope 113 (3) : 484 ~ 491

Bluestone CD / 1990 / Frequency of bacteria isolated from middle ear effusion of children from the United states, Finland, Japan, and Denmark / Ann Otol Rhinol Laryngol 99 (

Bluestone CD / 1995 / Clinical practice guideline on otitis media with effusion in young children: Strengths and weaknesses / Otolaryngol Head & Neck Surg 112 (4) : 507 ~

DeMaria TF / 1984 / Experimental otitis media with effusion following middle ear inoculation of nonviable H. Influenzae / Ann Otol Rhinol Laryngol 93 (1) : 52 ~ 56

Diamond G / 2000 / The innate immune response of the repiratory epithelium / Immunol Rev 173 : 27 ~ 38

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