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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Infection, inflammation and autoimmunity have been associated with pathogenesis of atherosclerosis.
Nucleated cells express Heat Shock Protein (HSP), evolutionary highly conserved molecules, in response to
environmental stress with inflammation. For carotid atherosclerosis and myocardial infarction, an association with
an increase in anti-HSP 65 antibodies has been demonstrated. But data regarding HSP in ischemic stroke are yet
sparse. The aim of our study was to investigate whether ischemic stroke is associated with a humoral immune
response to HSP. Methods: This case-control study includes a complete profile of anti-HSP 60/70 antibody and
HSP 60/70 proteins in acute ischemic stroke patients. Eighty-eight patients with acute ischemic stroke and 90 controls
were evaluated for conventional risk factor, and levels of HSP protein and antibodies. The levels of IgG antibody
to HSP 60/70 and circulating HSP 60/ 70 proteins were measured by emzyme-linked immunosorbent assay.
Results: Ischemic stroke was connected with a significant elevation of anti-HSP60 and 70 antibodies levels and
HSP 70 protein compared with controls (p<0.001). The multifactorial logistic regression analysis showed that
increased levels of anti-HSP 60 and 70 IgG antibodies were independent markers for stroke. Conclusions: Our
study suggest that expression of HSP may be a marker in the development of atherosclerosis, if atherosclerosis is
considered as an immune disease.
(Korean Journal of Stroke 2005;7(2): 151~158)
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