Histamine이 기도상피세포에서 Rhinovirus-16감염에 미치는 영향

정유삼; 권현자; 이봉재; 장용주; 이시형

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자료유형: 학술저널

저자정보: 정유삼 권현자 이봉재 장용주 이시형

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제2호

발행연도: 2006.1

수록면: 182 - 186 (5page)

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Background and Objectives：It is not known if allergies promote rhinovirus infections or aggravate the symptoms of common cold due to rhinoviruses. Histamine is an important immune mediator that induces symptoms of allergic rhinitis and asthma. We therefore investigated the effect of histamine on rhinovirus-16 infection in airway epithelial cells. Materials and Method：A549 cells were incubated for 24 hours with rhinovirus, histamine (10-5, 10-4, or 10-3 M), both, or neither. Mean fluorescence intensity (MFI) of intercellular adhesion molecule-1 (ICAM-1) was estimated by flow cytometry, and secretion of IL-6 and IL- 8 was measured by ELISA. Viral titers of rhinovirus-16 were measured by their cytopathic effects on lung fibroblasts after serial dilution. Results：Histamine and rhinovirus acted synergistically to increase IL-8 secretion and enhance viral titer in the supernatants of cultured cells. In contrast, histamine and rhinovirus did not show synergistic effects on cell surface expression of ICAM-1 or on IL-6 secretion. Conclusion：Histamine may potentiate the secretion of IL-8 after rhinovirus-16 infection and may increase rhinovirus-16 titer in airway epithelial cells in a dose dependent manner. (Korean J Otolaryngol 2006;49:182-6)

#히스타민·코감기바이러스·IL-8·IL-6·ICAM-1. #Histamine·Rhinovirus·IL-8·IL-6·ICAM-1.

참고문헌 (20)

참고문헌 신청

/ 1991 / Experimental rhinovirus 16 infection potentiates histaminerelease after antigen bronchoprovocation in allergic subjects 144 : 1267 ~ 73

/ 1993 / Activation by histamine of bronchial epithelial cells fromnonasthmatic subjects 9 : 411 ~ 7

/ 1994 / Histamine induces IL-6 production by human endothelial cells 98 : 344 ~ 9

/ 1994 / Histamine induces interleukin-8 secretion by endothelial cells 84 : 2229 ~ 33

/ 1994 / Influence of interleukin-8 challenge in the nasal mucosa inatopic and nonatopic subjects 150 : 1108 ~ 13

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