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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
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- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제41권 제12호
- 발행연도
- 2019.1
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- 1 - 6 (6page)
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Background: Programmed cell death ligand 1 (PD-L1) is an immune checkpoint molecule that attenuates the immune response. PD-L1 contributes to failed antitumor immunity; thereby, blockade of PD-L1 with monoclonal antibody enhances the immune response. Recently, it was reported that PD-L1 was regulated by protein 53 (p53). Besides, cytokeratin 17 (CK17) is thought to be a diagnostic marker of oral squamous cell carcinoma (OSCC). Our aim was to evaluate the correlation between the immunohistochemical expression of PD-L1, p53 and CK17 with clinicopathological characteristics and disease-specific survival in patients with OSCC. Methods: A total of 48 patients with OSCC were included in this study. Immunohistochemical staining was performed to evaluate the correlation among the expressions of PD-L1, p53 and CK17, and furthermore the correlation among various clinicopathological factors, PD-L1, p53 and CK17. Results: The positive rate of p53, CK17, PD-L1 (tumor cells) and PD-L1 (tumor-infiltrating lymphocytes) was 63.2%, 91.7%, 48.9% and 57.1%. A statistically significant correlation between p53 expression and T stage and TNM stage (p = 0.049, p = 0.03, respectively) was observed. Also, a statistically significant correlation between p53 and PD-L1 (TCs) expression (p = 0.0009) was observed. Five-year disease-specific survival rate was not significantly correlated with gender, TNM stage, p53 expression, PD-L1 expression and CK17 expression. Conclusion: The expression of p53 and PD-L1 shows significantly positive correlation in oral squamous cell carcinoma in tumor cells. Also, a significant correlation between p53 expression and T stage and TNM stage was observed. No other significant correlation between PD-L1 staining or CK17 and clinical or pathologic characteristics was identified.
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참고문헌 (19)
참고문헌 신청
Sharmal P / 2015 / The future of immune checkpoint therapy / Science 348(6230):56~61
Maruse Y / 2018 / Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma / Int. J. Oral Maxillofac. Surg 47:836~845
Yueh-Min Lin / 2015 / High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma / PLOS ONE 10(11):e0142656
Pfeifer GP / 1997 / Mutagenesis in the P53 gene / Biochim Biophys Acta 1333(1):M1~M8
Elias J / 2014 / The p53 protein and its molecular network: modelling a missing link between DNA damage and cell fate / Biochim Biophys Acta 1844(1 Pt B):232~247
Maruse Y / 2018 / Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma / Int. J. Oral Maxillofac. Surg 47:836~845
Yueh-Min Lin / 2015 / High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma / PLOS ONE 10(11):e0142656
Pfeifer GP / 1997 / Mutagenesis in the P53 gene / Biochim Biophys Acta 1333(1):M1~M8
Elias J / 2014 / The p53 protein and its molecular network: modelling a missing link between DNA damage and cell fate / Biochim Biophys Acta 1844(1 Pt B):232~247
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