비용종을 동반한 부비동염에서 비내 배양검사와포도상구균 외독소(Staphylococcus Aureus Exotoxin)Specific IgE의 연관에 관한 연구

윤진호; 하종수; 강일규; 김선태; 서일혜

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자료유형: 학술저널

저자정보: 윤진호 하종수 강일규 김선태 서일혜

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제7호

발행연도: 2007.1

수록면: 596 - 601 (6page)

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Background and Objectives：Staphylococcus aureus (S. aureus) exotoxins (SE) have been implicated in the pathogenesis of chronic sinusitis with nasal polyposis (CRSwNP). The aim of this study was to identify the contribution of S. aureus exotoxin as allergen in the development of nasal polyp. Materials and Method：Nasal polyp and serum were obtained from 30 patients who underwent endoscopic sinus surgery for CRSwNP and 10 control turbinate mucosae were used. Nasal culture was done for S. aureus exotoxin A (SEA), S. aureus exotoxin B (SEB), and toxic shock syndrome toxin 1 (TSST-1) were measured using ImunoCAP method in nasal tisue and serum. The patients were divided into three groups：A, nasal polyp (+)/culture (+)；B, nasal polyp (+)/culture (-)；C, nasal polyp (-)/culture (-). Results：The culture for S. aureus was 27% in CRSwNP when compared to 10% in control. The specific IgE for S. aureus in serum was significantly expresed in nasal polyp (30% ) compared to control (0% ). Also the Group A showed a significant high rate of specific IgE (63% ) compared to Group B (18% ) and Group C (0% ) in serum. In nasal polyp tissue, the specific IgE has showed no specific diference betwen nasal polyp (7% ) and control (10% ). However, it was also increased in Group A (25% ), compared to Group B (0%) and Group C (11% ). Conclusion：Our results demonstrated that there was a correlation betwen nasal polyp and specific IgE levels to S. aureus exotoxin. These results suggest that S. aureus exotoxin can act as a traditional allergen and induce the inflamatory reaction in CRSwNP. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :596-601)

#황색포도상구균 외독소·특이면역 글로불린 E ·비용종. #Staphylococcus aureus exotoxin· Specific IgE· Nasal polyp.

참고문헌 (20)

참고문헌 신청

/ / The microbiology of chronic rhinosinusitis : 143 ~ 5

/ 1999 / Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-derived superantigens SEA and SEB in children with atopic dermatitis 103 : 119 ~ 124

/ 2001 / A superantigen hypothesis for the pathogenesis of chronic hypertrophic rhinosinusitis, allergic fungal sinusitis, and related disorders 87 (3) : 181 ~ 188

/ 2003 / A superantigen hypothesis for the pathogenesis of chronic hyperplastic sinusitis with massive nasal polyposis 17 (6) : 321 ~ 326

/ 2003 / Bacterial superantigens 133 (3) : 299 ~ 306

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