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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제45권 제8호
발행연도
2002.1
수록면
765 - 770 (6page)

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Background and Objectives:Nitric oxide (NO) is an endogenous fre radical gas mediator, synthesized by a family of nitric oxide synthases (NOS). Established properties of NO of potential relevance to the formation of nasal polyps include vasodilatation, direct regulation of eosinophil and neutrophil function, and potentiation of histamine-induced plasma exuda-tion. Steroids are currently the most potent medication available for the treatment of nasal polyposis, but the exact mechani-and long-term topical steroid in nasal polyps. Materials and Method:Steroid-untreated nasal polyp patients (n=10), oral steroid-treated nasal polyp patients (n=10, prednisolone 30 mg per day for 7days) and topical steroid-treated nasal polyp patients (n=10, Fluticasone 100 μg per day for more than 1 month) underwent nasal endoscopy and biopsy of the polyps. The protein expresions of NOS in nasal polyp tissues were evaluated by immunohistochemistry. Results:chemical studies revealed that expression levels of proteins produced by three NOS isoenzymes were significantly decreased in steroid-treated nasal polyps when compared with steroid-untreated nasal polyps, and there was no diference in the effects betwen short-term systemic and long-term topical steroid treatment on nasal polyps. Conclusion:These results show that the expresions of constitutive NOS as well as inducible NOS in nasal polyp tissue were suppresed by steroid therapy. There was no diference in the NOS isoenzymes expression between short-term systemic and long-term topical steroid-treated polyps. (Korean J Otolaryngol 2002;45:765-70)

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