비특이적 과반응성 평가를 위한 저온저습공기 유발검사 및 비즙 내 면역글로불린 E 분석의 유용성

고영주; 최윤기; 경태석; 김대영; 황준하; 장태영; 김영효

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자료유형: 학술저널

저자정보: 고영주 최윤기 경태석 김대영 황준하 장태영 김영효

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제60권 제1호

발행연도: 2017.1

수록면: 19 - 23 (5page)

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Background and Objectives We aimed to evaluate the usefulness of cold dry air (CDA) provocation test in patients with non-allergic or allergic rhinitis. Subjects and Method Twenty-one patients (13 males and 8 females, mean age 36.9±17.6 years) with symptoms of rhinitis were enrolled. We classified patients into groups A (control group, n=9) and B (allergic group, n=12) according to their skin prick test results. Before and after CDA provocation (0℃, relative humidity＜10%, total 400 liters during 6 minutes), we evaluated changes in nasal symptoms. We collected serum, and nasal fluid before and after CDA provocation using the filter paper method. We measured serum and nasal fluid IgE levels, compared them between the groups, and evaluated the correlation between serum and nasal fluid IgE. Results After the CDA provocation, group B had more aggravation of symptoms than group A, with a statistical significance (for nasal obstruction, group A: 3.0±2.4, group B: 5.8± 3.4, p=0.049; for itching, group A: 1.0±1.6, group B: 3.8±3.4, p=0.045). The level of serum total IgE was significantly higher in group B (group A: 152.7±67.3 ng/mL, group B: 612.1±291.4 ng/mL, p=0.001). The titer of nasal fluid IgE was higher in group B, before and after the CDA challenge (before CDA, group A: 91.7±52.6 ng/mL, group B: 810.0±1042.3 ng/mL, p=0.029, after CDA, group A: 55.8±43.8 ng/mL, group B: 354.9±236.7 ng/mL, p=0.003). There was a significant correlation between the serum IgE and nasal fluid IgE levels after the CDA provocation test (R2=0.749, p＜0.001). Conclusion The CDA provocation test and measurement of nasal fluid IgE level could be useful for the evaluation of nonspecific hyper-reactivity. Korean J Otorhinolaryngol-Head Neck Surg 2017;60(1):19-23

#Allergic rhinitis #Immunoglobulin E #Nasal provocation tests.

참고문헌 (24)

참고문헌 신청

김영효 / 2010 / 알레르기성 비염 환자에서의 비강유발검사 후 비즙내 알부민을 이용한 비즙 채취 방법의 비교 / 대한이비인후과학회지 두경부외과학 53(10):615~619

김진국 / 2004 / 항원 유발이 비주기에 미치는 영향 / 대한이비인후과학회지 두경부외과학 47(12):1261~1266

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Braat JP / 1998 / Intranasal cold dry air is superior to histamine challenge in determining the presence and degree of nasal hyperreactivity in nonallergic noninfectious pere

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