지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1 - 7 (7page)
이용수
초록· 키워드
오류제보하기
Airway remodeling implies structural changes in the airways of patients with asthma. These changes are associated with poor long-term clinical outcomes and are attributed to chronic airway inflammation. However, some recent studies suggest that traditional anti-inflammatory therapies play a limited role in the modulation of airway remodeling. These findings have questioned the concept that persistent inflammation leads to airway remodeling. Growing evidence demonstrates that physical forces elicit a number of biologically relevant signals in the human body. The airway is exposed to a variety of mechanical stimuli, the most prominent of which is acute compressive stress caused by bronchoconstriction. A variety of in vitro studies have demonstrated that airway epithelial cells, as well as lung fibroblasts and smooth muscle cells, are responsive to mechanical stimuli. A recent in vivo study has shown that airway remodeling can be promoted simply by episodic administration of an inhaled bronchoconstrictor, methacholine. This result suggests another possibility of the association between airway remodeling and mechanical stimuli. However, further studies are required using well-designed, 3-dimensional in vitro experimental models as well as more patients with varying severities of asthma. These studies will help understand the interplay between mechanical and inflammatory contributions to airway remodeling.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Al-Muhsen S / 2011 / Remodeling in asthma / J Allergy Clin Immunol 128 : 451 ~ 462
Bishop JE / 1993 / Cyclic mec
Breen EC / 1999 / Calcyclin gene expression is increased by mechanical strain in fibroblasts and lung / Am J Respir Cell Mol Biol 21 : 746 ~ 752
Choe MM / 2006 / Extracellular matrix remodeling by dynamic strain in a three-dimensional tissue-engineered human airway wall model / Am J Respir Cell Mol Biol 35 : 306 ~ 313
Durrani SR / 2011 / What effect does asthma treatment have on airway remodeling? Current perspectives / J Allergy Clin Immunol 128 : 439 ~ 448
Bishop JE / 1993 / Cyclic mec
Breen EC / 1999 / Calcyclin gene expression is increased by mechanical strain in fibroblasts and lung / Am J Respir Cell Mol Biol 21 : 746 ~ 752
Choe MM / 2006 / Extracellular matrix remodeling by dynamic strain in a three-dimensional tissue-engineered human airway wall model / Am J Respir Cell Mol Biol 35 : 306 ~ 313
Durrani SR / 2011 / What effect does asthma treatment have on airway remodeling? Current perspectives / J Allergy Clin Immunol 128 : 439 ~ 448
이 논문의 저자 정보
최근 본 자료
댓글(0)
0