집먼지 진드기 유도성 기도개형의 기관지 천식 마우스모델

이숙영; 김승준; 김치홍; 안중현; 박성학; 김관형; 문화식; 송정섭; 김영실; 권순석; 김영균

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자료유형: 학술저널

저자정보: 이숙영 김승준 김치홍 안중현 박성학 김관형 문화식 송정섭 김영실 권순석 김영균

저널정보: 대한천식알레르기학회(구 대한알레르기학회) 천식 및 알레르기 천식 및 알레르기 제24권 제3호

발행연도: 2004.1

수록면: 310 - 317 (8page)

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Background: Although murine models have been useful in understanding acute airway inflammation in asthma, the ovalbumin induced murine models of asthma have significant limitations in study of airway remodeling. Objective: We investigated the Dermatophagoides farinae (Der f) induced the asthmatic mouse model of airway remodeling. Method: Six-week-old female BALB/c mice were divided into four groups according to adjuvant. After BALB/c were sensitized to Der f and exposed to Der f via nasal inhalation a week for 6 weeks, repeated Der f exposure were done on 3 days/week for 6 weeks to induce chronic asthma. Twenty-four hour after the final antigen challenge, bronchial responsiveness was measured, and bronchoalveolar lavage and histologic examinations were carried out. Result: The number of inflammatory cells and eosinophil in bronchoalveolar lavage fluid (P＜0.01), serum total IgE (P＜0.01) and Der f-specific IgG1 (P＜0.01) in all experimental group were significantly more increased than those in control group at 6 weeks and 12 weeks after immunization of Der f. Complete Freund's adjuvant group showed statistically significant differences in goblet cell numbers, thickness of peribronchial smooth muscle, degree of subeptithelial fibrosis (P＜0.01) and airway hyperresponsiveness to methacholine (P＜0.01) compared those with control group at 6 and 12 weeks. Conclusion: These data suggest that the Der f-induced asthmatic mouse model of airway remodeling using complete Freund's adjuvant may be useful in study of chronic asthma.

#Asthma #Models #Fibrosis

참고문헌 (23)

참고문헌 신청

/ 1996 / A theoretical analysis of the effect of airway smooth muscle load on airway narrowing 153 : 83 ~ 89

/ 1997 / Perhaps airway smooth muscle dysfunction contributes to asthmatic bronchial hyperresponsiveness after all 17 : 144 ~ 146

/ 1998 / The TH1/TH2 paradigm in allergy 3 : 233 ~ 244

/ 1999 / Airway remodeling and persistent airway obstruction in asthma 104 : 509 ~ 516

/ 1999 / Airway wall remodelling: does it occur and what does it mean? 29 : 1457 ~ 1466

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소속기관 가톨릭대학교

주요연구분야 의약학 > 임상의학 > 내과학

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