편도 편평세포암종에서 Ku70/80, p53,  Epidermal Growth Factor Receptor and Cyclooxygenase-2 의 발현과 예후와의 관련성

문병재; 남순열; 김상윤; 노종렬; 최승호; 이상욱; 조경자

추천

검색

자료유형: 학술저널

저자정보: 문병재 남순열 김상윤 노종렬 최승호 이상욱 조경자

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제1호

발행연도: 2008.1

수록면: 70 - 76 (7page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

The aim of this study was to find out if Ku70/80, p53, EGFR and COX-2 expressions are associated with prognostic variables and to examine the survival rate in tonsillar squamous cell carcinoma. Subjects and Method： From October 1991 to April 2006, 52 cases of paraffin-embedded tonsillar specimens were obtained by surgical resection in the Asan Medical Center. All tissue samples were subjected to immunohistochemical staining for Ku70/80, p53, EGFR and COX-2. Clinical factors such as age, treatment modality, TNM stage were evaluated nad detailed analyses were performed regarding the relationship between the expression of molecular markers, overall survival and disease free survival rates. Results：In the Ku70 expression, there were no cells that did not stain and 3 cases where less than 75% of cells stained positive. In the Ku80 expression, there was one case that did not stain and 3 cases where less than 75% of cells that stained positive. The positivity of p53, EGFR and COX-2 was 19% (10/52), 2% (1/52), 50% (26/52), respectively. There was a significant correlation between p53 and survival (overall and disease free) in the univariate analysis (p=0.049, p=0.017). However, there was no correlation in the multivariate survival analysis (p=0.187, p=0.078). Conclusion：This study finds that the expression of p53 correlates with an unfavorable prognosis in tonsillar squamous cell carcinoma. The p53 protein can be a biological marker for prediction of prognosis in tonsillar squamous cell carcinoma. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:70-6)

#Tonsillar neoplasms·Immunohistochemistry·Biological markers.

참고문헌 (21)

참고문헌 신청

Alimirah F / 2007 / Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1: Implications for cancer cell fate determination after genot

Atula T / 2006 / Cyclooxygenase-2 expression in squamous cell car cinoma of the oral cavity and pharynx: Association to p53 and clinical outcome / Oncol Rep 16 (3) : 485 ~ 4

Baek CH / 1995 / Immunohistochemical Study of p53 expression in head and neck squamous cell carcinoma / Korean J Otolaryngol-Head Neck Surg 38 (3) : 407 ~ 412

Calzolari A / 1997 / Immunohistochemical vs molecular biology methods. Complementary techniques for effective screening of p53 alterations in head and neck cancer / Am J Cli

Caminero MJ / 1996 / Detection of p53 protein in oropharyngeal carcinoma. Prognostic implications / Arch Otolaryngol Head Neck Surg 122 (7) : 769 ~ 772

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!