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자료유형
학술저널
저자정보
Wang, Jun (Department of Radiation Oncology, the Fourth Hospital of HeBei Medical University) Yu, Jin-Ming (Academy of Medical Sciences of Shandong, Key Laboratory of Radiation Oncology and Department of Radiation Oncology, Tumor Hospital of Shandong) Jing, Shao-Wu (Department of Radiation Oncology, the Fourth Hospital of HeBei Medical University) Guo, Yin (Department of Radiation Oncology, the Fourth Hospital of HeBei Medical University) Wu, Ya-Jing (Department of Radiation Oncology, the Fourth Hospital of HeBei Medical University) Li, Na (Department of Radiation Oncology, the Fourth Hospital of HeBei Medical University) Jiao, Wen-Peng (Department of Radiation Oncology, the Fourth Hospital of HeBei Medical University) Wang, Li (Department of Radiation Oncology, the Fourth Hospital of HeBei Medical University) Zhang, Yan-Jun (Department of Radiation Oncology, the Fourth Hospital of HeBei Medical University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제14호
발행연도
2014.1
수록면
5,889 - 5,893 (5page)

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Over-expression of epidermal growth factor receptor (EGFR) has been identified as a common feature associated with clinical outcome in many types of cancer, including squamous cell carcinoma of the oesophagus (SCCO). However, the clinical importance of EGFR over-expression in SCCO remains unsettled as conflicting results exist. Therefore we carried out the present meta-analysis of published studies for clarification. A total of 13 studies including 1, 150 patients were enrolled. EGFR over-expression was positive in 722 of these cases. With EGFR over-expression, patients had higher depth of invasion, vascular invasion, and poor prognosis. However, expression had no relation with degree of differentiation, histological grade, lymph node metastasis, clinical stage or lymphatic invasion. EGFR over-expression is probably a valuable predictor for the T stage, vascular invasion and OS, and it could be used as a poor prognosis indicator for the esophageal SCC patients. Targeting therapy to EFGR should be considered to the combined treatment in SCCO.

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