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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제6호
- 발행연도
- 2007.1
- 수록면
- 387 - 392 (6page)
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Background : Abnormal over-expression or gene amplification of epidermal growth factor
receptor (EGFR) is important in the prognosis of non-small cell lung cancer (NSCLC). We
investigated the frequency of EGFR protein expression and gene amplification, and the correlation
between EGFR status and survival in NSCLC. Methods : We examined 360 cases
of microarrayed NSCLC tissues for the EGFR protein expression and EGFR gene amplification
using immunohistochemistry and fluorescent in situ hybridization. Results : EGFR protein
expression and EGFR gene amplification occurred in 110 cases (30.6%) and 24 cases
(6.7%), respectively. EGFR protein expression and gene amplification were more frequent in
squamous cell carcinoma than in adenocarcinoma. Differences in EGFR protein expression
did not dramatically affect survival curves (p=0.740), but differences in gene amplification did
(p<0.05): EGFR gene amplification was associated with a lower 5-year survival rate. Conclusion
: EGFR protein expression and gene amplification showed moderate correlation with
each other. EGFR gene amplification predicted a poor prognosis, whereas EGFR protein
expression did not.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
/ / Epidermal growthfactor receptor expression in squamous cell lung carcinomas animmunohistochemical and gene analysis in formalin-fixed : 295 ~ 302
/ / Role of epidermal growth factor in carcinogenesis : 1030 ~ 7
/ 1996 / Lack of prognostic significanceof epidermal growth factor receptor and the oncoproteinp185HER-2 in patients with systemically untreated non-small-celllung cancer an
/ 1997 / Overexpression of the epidermal growth factor receptorand its ligand transforming growth factor alpha is frequent inresectable non-small cell lung cancer but does n
/ 1998 / Correlation between moleculargenetic analyses and immunohistochemical evaluation of theepidermal growth factor receptor and p185HER2 18 : 2529 ~ 2534
/ / Role of epidermal growth factor in carcinogenesis : 1030 ~ 7
/ 1996 / Lack of prognostic significanceof epidermal growth factor receptor and the oncoproteinp185HER-2 in patients with systemically untreated non-small-celllung cancer an
/ 1997 / Overexpression of the epidermal growth factor receptorand its ligand transforming growth factor alpha is frequent inresectable non-small cell lung cancer but does n
/ 1998 / Correlation between moleculargenetic analyses and immunohistochemical evaluation of theepidermal growth factor receptor and p185HER2 18 : 2529 ~ 2534
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