Overall Survival of Filipino Patients with Squamous Cell Carcinoma of the Head and Neck: A Single-Institution Experience

Albano, Pia Marie; Lumang-Salvador, Christianne; Orosa, Jose; Racelis, Sheryl; Leano, Modesty; Angeles, Lara Mae; Ramos, John Donnie

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자료유형: 학술저널

저자정보: Albano, Pia Marie (Research Center for the Natural and Applied Sciences, College of Science, University of Santo Tomas) Lumang-Salvador, Christianne (Department of ENT Head and Neck Surgery, Mariano Marcos Memorial Hospital and Medical Center) Orosa, Jose (Graduate School, College of Science, University of Santo Tomas) Racelis, Sheryl (Department of Pathology, Mariano Marcos Memorial Hospital and Medical Center) Leano, Modesty (Department of Pathology, Mariano Marcos Memorial Hospital and Medical Center) Angeles, Lara Mae (Graduate School, College of Science, University of Santo Tomas) Ramos, John Donnie (Research Center for the Natural and Applied Sciences, College of Science, University of Santo Tomas)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제8호

발행연도: 2013.1

수록면: 4,769 - 4,774 (6page)

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This paper is the first to present the incidence and overall survival of patients with squamous cell carcinoma of the head and neck (SCCHN) from the extreme northern part of the Philippines. We retrospectively retrieved the records of patients with histologically-confirmed squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx at the Mariano Marcos Memorial Hospital and Medical Center, Ilocos Norte, Philippines, from 2003 to 2012 and analysed prognostic factors associated with survival. Of the 150 cases, only 80 (53.3%) were still living when the study was terminated. Median age at initial diagnosis was 61.5 years and the male to female ratio was 7:3. The majority of the cases had tumours in the oral cavity (50.7%), followed by the larynx (36.7%). Sex (log rank=1.94, p value/${\alpha}$=0.16), tumor site (log rank=0.02, p value/${\alpha}$=0.90), tumor grade (log rank=1.74, p value/${\alpha}$=0.42), and node stage (log rank=0.07, p value/${\alpha}$=0.80) were not shown to be associated with the survival of our cases. Only 45 (30.0%) had no regional lymph node involvement (N0) at presentation and 12 (8.0%) had already developed distant metastases. Among the 150 patients, 71 (47.3%) were not able to receive treatment of any kind. Oddly, treatment (log rank=1.65, p value/${\alpha}$=0.20) was also shown to be not associated with survival. The survival rate of those who underwent surgery, radiotherapy, or both was not statistically different from those who did not receive any treatment. Only the tumor stage (log rank=4.51, p value/${\alpha}$=0.03) was associated with patient survival. The overall mean survival was 49.3 months, with survival rate diminishing from 88.3% during the 1st year to 1.80% by end of the study. This relatively low survival rate of our cases only reflects their poor access to quality diagnostic and treatment facilities.

#Squamous cell carcinoma of the head and neck #survival #treatment #tumor stage #Philippines

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Albano, Pia Marie

소속기관 Research Center for the Natural and Applied Sciences, College of Science, University of Santo Tomas