구강 편평세포암에서 EGFR과 C-erb-B2 유전자 발현에 관한 면역조직화학적 연구

조원; 조재식; 이종원; 김해송; 박근재

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자료유형: 학술저널

저자정보: 조원 (전남대학교 의과대학 이비인후과학교실) 조재식 (전남대학교 의과대학 이비인후과학교실) 이종원 (전남대학교 의과대학 이비인후과학교실) 김해송 (전남대학교 의과대학 이비인후과학교실) 박근재 (전남대학교 의과대학 이비인후과학교실)

저널정보: 대한기관식도과학회 대한기관식도과학회지 대한기관식도과학회지 제2권 제2호

발행연도: 1996.1

수록면: 200 - 212 (13page)

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The clinical staging systems for oral squamous cell carcinoma is limited as a prognostic indicatior because of different biological characteristics of cancer in this region and variable microenvironment depending on subsites, there have been study to determine prognosis by evaluating malignancy, that is the nature of tumor cells. Many studies have been tried to determine prognostic indicator in various malignancies for the evaluation of differentiation capacity and the expression of oncogene product. EGF make a role in cellular growth and differentiation and to be essential in cellular survival. EGFR is an intergral membrane protein, stimulate cellular differentiation and hormonal secretion, and has structural homology with V-erb-B transforming protein. Recent reports have demonstrated that EGFR is overexpressed in stomach, breast, vagina, dermis, head and neck, genitourinary and lung tumors, and possibly used as a tumor marker. In head and neck region, most of studies were mainly carried out on laryngeal squamous cell carcinoma. In the present study, immunohistochemical study for EGFR and C-erb-B2 gene in paraffin sections of 45 squamous cell carcinoma in oral cavity was performed to evaluate the presense of EGFR and C- erb-B2 gene in this lesion, to evaluate them as a prognostic indicator by analysing the correlation between these expression and subsites, primary stages, clinical stages, pathologic grades, neck node metastasis, recurrences and treatment results, and to determine relation between EGFR and C-erb-B2 gene.

#EGFR #C-erb-B2 #Squamous cell carcinoma

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