Cisplatin에 내성을 가지는 두경부 세포주에서 Docetaxel의 교차내성에 관한 연구

전경명; 왕수건; 이진춘; 이병주; 김선희; 구형준

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자료유형: 학술저널

저자정보: 전경명 왕수건 이진춘 이병주 김선희 구형준

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제5호

발행연도: 2005.1

수록면: 651 - 655 (5page)

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Background and Objectives：Treatment of head and neck cancer with cisplatin-based combination chemotherapy has yielded increased complete response rates. In spite of the initial good response, recurrent cancer after chemotherapy does not respond to cisplatin based chemotherapy. In recent years, the analogues of taxol have used in a new chemotherapy treatments for head and neck cancer. The purpose of this study was to develop the acquired resistance to cisplatin in head and neck cancer cell line and to study the cross-resistance of docetaxel and 5-fluorouracil (5-FU) as compared to the parental cells in vitro. Subjects and Method：Two different human head and neck cancer cell lines (PNUH-12, SNU-899) were studied. We developed two cisplatin resistant cell lines (PNUH-12 R1, SNU-899 R1) by exposing them to near continuous increasing concentration of cisplatin. The morphology, growth curve of resistant cell lines were studied and the resistance of these cell lines to the cisplatin, docetaxel and 5-FU were compared to that of parental cells by MTT assay. Results：The pattern of growth and shape of PNUH-12 R1 and SNU 899 R1 cell lines showed similarity to their parent cell lines. The growth curve of these cell lines were suppressed when compared with the parental cells. When compared to the parental cells, PNUH-12 R1 cells were 2.0-fold, 3.8-fold, and 1.4-fold resistant, and SNU 899 R1 cells 3.5-fold, 6.7-fold, and 15.0-fold resistant to cisplatin, docetaxel and 5-FU, respectively. Conclusion：In our study, cisplatin resistant cell lines of head and neck cancer have strong cross-resistance to docetaxel. However, there was difference in cross-resistance to 5-FU between these cell lines.

#Cisplatin·Docetaxel·Fluorouracil·두경부암. #Cisplatin·Docetaxel·Fluorouracil·Head and neck neoplasms.

참고문헌 (18)

참고문헌 신청

/ neoplasma1994 / Human larynx carcinoma cells resistant to cis-diamminedichloroplatinum : 171 ~ 6

Beauvillain C / 1997 / Final results of a randomized trial comparing chemotherapy plus radiotherapy with chemotherapy plus surgery plus radiotherapy in locally advanced resec

Bensmaine M / 1996 / Neoadjuvant chemotherapy with cisplatin-vindesine-5-fluorouracil and folinic acid for locally advanced head and neck carcinoma 19 : 356 ~ 62

Ferguson PJ / 1995 / Mechanisms of resistance of human tumours to anticancer drugs of the platinum family:A review 24 : 242 ~ 52

Glisson BS / 2002 / Phase II trial of docetaxel and cisplatin combination chemotherapy in patients with squamous cell carcinoma of the head and neck 20 : 1593 ~ 9

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