Triptolide와 Cisplatin 병용이 두경부 종양 세포주  세포자멸사에 미치는 효과

남영진; 송달원; 여창기; 김동은; 박종욱

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자료유형: 학술저널

저자정보: 남영진 송달원 여창기 김동은 박종욱

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제10호

발행연도: 2008.1

수록면: 894 - 902 (9page)

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Cisplatin (CP) is a widely used agent for chemotherapy of head and neck squamous cell carcinoma but some tumor cell shows resistance to CP. Accordingly, it is necessary to seek a method to increase the sensitivity of tumor cell to CP. This study was conducted to investigate whether Triptolide (TP) is effective in the inhibition of proliferating head and neck cancer cell and sensitizes cancer cells to CP. Materials and Method：To assess how the combination of TP and CP influence apoptosis of head and neck cancer cell, AMC-HN4 cells were treated with different concentrations of TP and/or CP. Then, their growth was analyzed by XTT assay and the degree of apoptosis was analyzed by flow cytometry. Results：The combination of TP and CP increased suppression of the growth of tumor cells more significantly and enhanced apoptosis more than that of TP or CP alone, and suppressed expression of anti-apoptotic protein. Conclusion：This study showed that TP alone had antitumor activity in AMC-HN4 cells, and the combination of TP or CP also might sensitize head and neck cancer cell to CP by suppressing the expression of antiapoptotic protein. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:894-902)

#Head and neck cancer·Triptolide·Cisplatin·Apoptosis.

참고문헌 (20)

참고문헌 신청

Carter BZ / 2006 / Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells / Blood 108 (2) : 630 ~ 637

Chang WT / 2001 / Triptolide and chemotherapy cooperate in tumor cell apoptosis: A role for the p53 pathway / J Biol Chem 276 (3) : 2221 ~ 2227

Harrison LB / 1999 / Head and Neck Cancer: A Multidisciplinary Approach / Lippincott-Raven Publishers : 253 ~ 352

Jiang XH / 2001 / Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells / Oncogene 20 (55) : 8009

Katori H / 2005 / Comparison of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by radiation vs concurrent chemoradiotherapy with TPF in

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