지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 151 - 156 (6page)
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초록· 키워드
오류제보하기
5-Fluorouracil (5-FU) is commonly used for the therapy of colon cancer; however, acquired resistance to 5-FU is a critical barrier to successful treatment and the primary cause of chemotherapy failure. Epithelialmesenchymal transition (EMT) is a process whereby cells undergo alterations in morphology and molecular characteristics promoting tumor progression and metastasis. Accumulating evidence shows that transition from epithelial to mesenchymal phenotype in cancer cells is associated with their resistance to chemotherapy. However, it is still poorly understood whether EMT is involved in acquired resistance to 5-FU. In this study, we developed an in vitro cell model, 5-FU-resistant HT-29 colon cancer cells, and characterized the differences in cellular morphology and molecular alterations between parental and resistant cells. In accord with mesenchymal-like morphology of 5-FU-resistant HT-29 cells, the expression of the mesenchymal marker fibronectin was significantly increased in these cells in comparision with that in the parental cells. Of interest, we also found a marked increase in the expression of EMT-inducing transcription factors Twist, Zeb1, and Zeb2. Finally, 5-FU-resistant cells showed enhanced migration in comparison with parental HT-29. Taken together, these results indicate that EMT could be associated with 5-FU resistance acquired by HT-29 cells. A specific role of each transcription factor found in this study will require further investigation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
Siegel, R. / 2014 / Colorectal cancer statistics, 2014 / Ca Cancer J. Clin. 64:104~117
Douillard, J. Y. / 2000 / Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial / Lancet 355:1041~1047
Longley, D. B. / 2003 / 5-fluorouracil:mechanisms of action and clinical strategies / Nat. Rev. Cancer 3:330~338
Park, I. J. / 2012 / Neoadjuvant treatment response as an early response indicator for patients with rectal cancer / J. Clin. Oncol. 30:1770~1776
Thiery, J. P. / 2002 / Epithelial-mesenchymal transitions in tumour progression / Nat. Rev. Cancer 2:442~454
Douillard, J. Y. / 2000 / Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial / Lancet 355:1041~1047
Longley, D. B. / 2003 / 5-fluorouracil:mechanisms of action and clinical strategies / Nat. Rev. Cancer 3:330~338
Park, I. J. / 2012 / Neoadjuvant treatment response as an early response indicator for patients with rectal cancer / J. Clin. Oncol. 30:1770~1776
Thiery, J. P. / 2002 / Epithelial-mesenchymal transitions in tumour progression / Nat. Rev. Cancer 2:442~454
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UCI(KEPA) : I410-ECN-0101-2016-513-001692652