메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background and Objectives:The pathogenesis of allergic rhinitis has not been fully understood. The role of stem cell factor (SCF)instillation of SCF in mice with experimentaly-induced allergic rhinitis. Materials and Method:Male BALB-c mice were intraperitonially sensitized to ovalbumin mixed with aluminum hydroxide and were challenged with aerosols of ovalbumin. Recombinant murine SCF was directly instilled to both nasal cavities. Sneezing and nose-rubbing act of the mice were checked by symptom scores. Nasal lavage fluid (NLF) was collected and histamine levels in the NLF were measured. The eosinophils in the inferior turbinate of the mice were counted at the coronal section of the skull. Results:The symptom scores checked 1 hour after intranasal instillation of 50 nM SCF and 50 nM SCF were 29± 8 (mean± S.D.) and 31± 10, respectively. They were significantly diferent from those of the control group (18± 5). Histamine levels of NLF colected 1 hour after intranasal instillation of 500 nM SCF were 3.62 1.8 nM and were significantly diferent from those of the control group (1.31± 0.4 nM)of eosinophils in the inferior turbinate of mice counted 24 hours after intranasal instillation of 500 nM SCF was 17.6± 3.2 and was significantly diferent from those of the control group (11.2± 3.5). Conclusion:Stem cell factor may play an important role in the pathogenesis of allergic rhinitis. (Korean J Otolaryngol 2003 ;46 :110-4)

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0