공업용 본드가스 흡입 후 생쥐 코점막 호흡상피의 형태학적 변화

이영훈; 장혁순; 송태현; 한동열; 김동욱; 강기훈; 이병돈; 오천환

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자료유형: 학술저널

저자정보: 이영훈 장혁순 송태현 한동열 김동욱 강기훈 이병돈 오천환

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제45권 제7호

발행연도: 2002.1

수록면: 671 - 681 (11page)

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연구주제

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연구배경

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연구방법

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연구결과

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Background and Objectives：Social awareness of the narcotic effects of industrial adhesive vapors have been aroused by some teens who are reported to inhale these vapors to get the narcotic effects. When inhaled, the toxic effects of these chem-y. The efects of industrial adhesive vapors on the respiratory epithelium are unclear so far. Materials and Method：This was designed to study the morphological changes after exposure of the chemicals on the nasal mucosa in mice. Young healthy mice were exposed to industrial adhesive vapor (mixtures of acetone 5212± 1268 ppm, c-hexane 3757± 711 ppm, methyl cyclopentane 1820± 375 ppm, n-hexane 139± 30 ppm, toluene 0.9± 1.4 ppm) for 20 min, once daily for 3 days, 5 days, 7 days, and 14 days. After adhesive vapor exposure, mice respiratory mucosa were excised, fixed in 4% paraformaldehyde for immuno-histochemistry and in 2.5% glutaraldehyde -1.5% paraformaldehyde for transmission electron microscopy and in 2.5% glutaraldehyde for scanning electron microscopy. Fixed tissues were procesed for imunohistochemistry and for el-ectron microscopy. Results：Celular degeneration and necrosis were sen on exposure day 3 and 5 which included erosion mnar cells and goblet cells were regenerated on day 7. Among the ciliated cells, most of the cells were replaced by cuboid ciliated cells. And the secretory patern of the goblet cells were also changed from the merocrine to apocrine type at same days of ex-posure. On the other hand, the PCNA immunochemical study revealed that positive cells were increased on day 5. Conclusion：These results sugest that the nasal mucosa of mice can be damaged to some extent by daily regular exposure of industrial adhesive vapor. However, it could have a potency of regeneration to cuboidal cells, which are thought to change into more (Korean J Otolaryngol 2002;45:671-81)

#비강점막·가스·흡입. #Nasal mucosa· Inhalation· Exposure.

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